Monocytes develop in the bone marrow and represent the primary type of mononuclear
phagocyte found in the blood. They were long thought of as a source for tissue …

Over the last three decades, it has become clear that the role of vitamin D goes beyond the
regulation of calcium homeostasis and bone health. An important extraskeletal effect of …

Conventional type 1 dendritic cells (cDC1) are thought to perform antigen cross-
presentation, which is required to prime CD8+ T cells,, whereas cDC2 are specialized for …

CD8 T cell-mediated autoimmune diseases result from the breakdown of self-tolerance
mechanisms in autoreactive CD8 T cells. How autoimmune T cell populations arise and are …

Dendritic cells (DCs) play critical roles in activating innate immune cells and initiating
adaptive immune responses. The functions of DCs were originally obscured by their overlap …

Type 1 diabetes (T1D) results from destruction of pancreatic beta cells by T cells of the
immune system. Despite improvements in insulin analogs and continuous blood glucose …

Adoptive immunotherapy with Tregs is a promising approach for preventing or treating type
1 diabetes. Islet antigen–specific Tregs have more potent therapeutic effects than polyclonal …

Immune tolerance is necessary to prevent the immune system from reacting against self, and
thus to avoid the development of autoimmune diseases. In this review, we discuss key …

Dendritic cells (DCs) are cells derived from the hematopoietic stem cells (HSCs) of the bone
marrow and form a widely distributed cellular system throughout the body. They are the most …

We examine the features, origin, turnover, and gene expression of pancreatic macrophages
under steady state. The data distinguish macrophages within distinct intrapancreatic …