Endophytic fungi: Key insights, emerging prospects, and challenges in natural product drug discovery

P Tiwari, H Bae - Microorganisms, 2022 - mdpi.com
Plant-associated endophytes define an important symbiotic association in nature and are
established bio-reservoirs of plant-derived natural products. Endophytes colonize the …

Fungal endophytes as efficient sources of plant-derived bioactive compounds and their prospective applications in natural product drug discovery: Insights, avenues …

A Singh, DK Singh, RN Kharwar, JF White, SK Gond - Microorganisms, 2021 - mdpi.com
Fungal endophytes are well-established sources of biologically active natural compounds
with many producing pharmacologically valuable specific plant-derived products. This …

Microbial drug discovery: 80 years of progress

AL Demain, S Sanchez - The Journal of antibiotics, 2009 - nature.com
Microbes have made a phenomenal contribution to the health and well-being of people
throughout the world. In addition to producing many primary metabolites, such as amino …

[PDF][PDF] A worldwide list of endophytic fungi with notes on ecology and diversity

M Rashmi, JS Kushveer, VV Sarma - Mycosphere, 2019 - mycosphere.org
Endophytic fungi are symptomless internal inhabits of plant tissues. They are implicated in
the production of antibiotic and other compounds of therapeutic importance. Ecologically …

Endophytes as in vitro production platforms of high value plant secondary metabolites

A Venugopalan, S Srivastava - Biotechnology advances, 2015 - Elsevier
Many reports have been published on bioprospecting of endophytic fungi capable of
producing high value bioactive molecules like, paclitaxel, vincristine, vinblastine …

Plant bioactive metabolites and drugs produced by endophytic fungi of Spermatophyta

R Nicoletti, A Fiorentino - Agriculture, 2015 - mdpi.com
It is known that plant-based ethnomedicine represented the foundation of modern
pharmacology and that many pharmaceuticals are derived from compounds occurring in …

Production of the anticancer drug taxol by the endophytic fungus Epicoccum nigrum TXB502: enhanced production by gamma irradiation mutagenesis and …

ESR El-Sayed, AG Zaki, AS Ahmed… - Applied Microbiology and …, 2020 - Springer
Taxol, a phyto-extracted diterpenoid, is the most commercially needed drug in cancer
chemotherapy. In spite of the microbial production of taxol being successful and prospective …

Microbial paclitaxel: advances and perspectives

ZR Flores-Bustamante, FN Rivera-Orduna… - The Journal of …, 2010 - nature.com
Paclitaxel is a potent and widely used antitumor agent. Considerable worldwide research
efforts have been carried out on different production alternatives. Since the description of the …

Aspergillus niger var. taxi, a new species variant of taxol‐producing fungus isolated from Taxus cuspidata in China

K Zhao, W Ping, Q Li, S Hao, L Zhao… - Journal of Applied …, 2009 - academic.oup.com
Aims: To characterize and identify a new taxol‐producing fungal strain HD86‐9 isolated from
Taxus cuspidata in China. Methods and Results: Taxol extracted from strain HD86‐9 was …

Production of valuable compounds by molds and yeasts

AL Demain, E Martens - The Journal of antibiotics, 2017 - nature.com
We are pleased to dedicate this paper to Dr Julian E Davies. Julian is a giant among
microbial biochemists. He began his professional career as an organic chemistry PhD …