The risk associated with organophosphorus nerve agents: from their discovery to their unavoidable threat, current medical countermeasures and perspectives
The first organophosphorus nerve agent was discovered accidently during the development
of pesticides, shortly after the first use of chemical weapons (chlorine, phosgene) on the …
of pesticides, shortly after the first use of chemical weapons (chlorine, phosgene) on the …
Comparative protective effects of HI-6 and MMB-4 against organophosphorous nerve agent poisoning
PM Lundy, MG Hamilton, TW Sawyer, J Mikler - Toxicology, 2011 - Elsevier
Abstract The oximes pralidoxime (2-PAM), its dimethanesulphonate salt derivative P2S, and
obidoxime (toxogonin) are currently licensed and fielded for the treatment of chemical …
obidoxime (toxogonin) are currently licensed and fielded for the treatment of chemical …
A comprehensive evaluation of the efficacy of leading oxime therapies in guinea pigs exposed to organophosphorus chemical warfare agents or pesticides
CM Wilhelm, TH Snider, MC Babin, DA Jett… - Toxicology and applied …, 2014 - Elsevier
The currently fielded pre-hospital therapeutic regimen for the treatment of
organophosphorus (OP) poisoning in the United States (US) is the administration of atropine …
organophosphorus (OP) poisoning in the United States (US) is the administration of atropine …
Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro
F Worek, T Seeger, M Goldsmith, Y Ashani… - Archives of …, 2014 - Springer
The potent human toxicity of organophosphorus (OP) nerve agents calls for the development
of effective antidotes. Standard treatment for nerve agent poisoning with atropine and an …
of effective antidotes. Standard treatment for nerve agent poisoning with atropine and an …
Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents
CL Cadieux, H Wang, Y Zhang, JA Koenig… - Chemico-biological …, 2016 - Elsevier
Currently fielded treatments for nerve agent intoxication include atropine, an acetylcholine
receptor antagonist, and pralidoxime (2PAM), a small molecule reactivator of …
receptor antagonist, and pralidoxime (2PAM), a small molecule reactivator of …
Reactivation of brain acetylcholinesterase by monoisonitrosoacetone increases the therapeutic efficacy against nerve agents in guinea pigs
JW Skovira, JC O'Donnell, I Koplovitz, RK Kan… - Chemico-biological …, 2010 - Elsevier
Current oxime therapies do not readily cross the blood–brain barrier to reactivate
organophosphorus nerve agent-inhibited cholinesterase (ChE) within the CNS. We …
organophosphorus nerve agent-inhibited cholinesterase (ChE) within the CNS. We …
Zebrafish as a model for acetylcholinesterase‐inhibiting organophosphorus agent exposure and oxime reactivation
JA Koenig, TL Dao, RK Kan… - Annals of the New York …, 2016 - Wiley Online Library
The current research progression efforts for investigating novel treatments for exposure to
organophosphorus (OP) compounds that inhibit acetylcholinesterase (AChE), including …
organophosphorus (OP) compounds that inhibit acetylcholinesterase (AChE), including …
[HTML][HTML] Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase
G Amitai, A Plotnikov, S Chapman, S Lazar… - Communications …, 2021 - nature.com
Government-sanctioned use of nerve agents (NA) has escalated dramatically in recent
years. Oxime reactivators of organophosphate (OP)-inhibited acetylcholinesterase (AChE) …
years. Oxime reactivators of organophosphate (OP)-inhibited acetylcholinesterase (AChE) …
Redox status in liver of rats following subchronic exposure to the combination of low dose dichlorvos and deltamethrin
MY Xu, P Wang, YJ Sun, HP Wang, YJ Liang… - Pesticide biochemistry …, 2015 - Elsevier
Organophosphates and pyrethroids are widely used pesticides with prominent toxicity to
humans. However, their joint toxicity has not been thoroughly investigated. In this study, we …
humans. However, their joint toxicity has not been thoroughly investigated. In this study, we …
Reactivation of organophosphate-inhibited human, Cynomolgus monkey, swine and guinea pig acetylcholinesterase by MMB-4: a modified kinetic approach
F Worek, T Wille, N Aurbek, P Eyer… - Toxicology and applied …, 2010 - Elsevier
Treatment of poisoning by highly toxic organophosphorus compounds (OP, nerve agents) is
a continuous challenge. Standard treatment with atropine and a clinically used oxime …
a continuous challenge. Standard treatment with atropine and a clinically used oxime …