Research elucidating the pathogenesis of systemic lupus erythematosus (SLE) has defined
two critical families of mediators, type I interferon (IFN-I) and autoantibodies targeting nucleic …

Autoimmune diseases are a group of disorders resulting from an alteration of immune
tolerance, characterized by the formation of autoantibodies and the consequent …

Immune deposits/complexes are detected in a multitude of tissues in autoimmune disorders,
but no organ has attracted as much attention as the kidney. Several kidney diseases are …

To detail the unmet clinical and scientific needs in the field of rheumatology. After a 2-year
hiatus due to the SARS-CoV-2 pandemic, the 22nd annual international Advances in …

Objective A blood-based biomarker is needed to assess lupus nephritis (LN) disease
activity, minimizing the need for invasive kidney biopsies. Long non-coding RNAs (lncRNAs) …

Introduction Systemic lupus erythematosus with antiphospholipid syndrome (SLE-APS)
represents a challenging SLE endotype whose molecular basis remains unknown. Methods …

Sex is a key variable in the regulation of human physiology and pathology. Many diseases
disproportionately affect one sex: autoimmune diseases, such as systemic lupus …

No single organ has received as much attention in systemic lupus erythematosus (SLE) as
the kidneys. During the period 2019–2022, the Annals of the Rheumatic Diseases published …

Background Monocytes-key regulators of the innate immune response-are actively involved
in the pathogenesis of systemic lupus erythematosus (SLE). We sought to identify novel …

Introduction Current therapeutic management of lupus nephritis (LN) fails to induce long-
term remission in over 50% of patients, highlighting the urgent need for additional options …