Phenotype-based compound screening has advantages over target-based drug discovery,
but is unscalable and lacks understanding of mechanism of drug action. A chemical-induced …

Overexpression of eIF4E is common in patients with various solid tumors and hematologic
cancers. As a potential anti-cancer target, eIF4E has attracted extensive attention from …

Abstract Purpose of Review To highlight recent results in targeting mRNA translation and
discuss the results and prospects of translation inhibitors in cancer therapy. Recent Findings …

Interactive networks of transcription factors (TFs) have critical roles in epigenetic and gene
regulation for cancer progression. It is required to clarify underlying mechanisms for …

The identification of the modes of action of bioactive compounds is a major challenge in
chemical systems biology of diseases. Genome-wide expression profiling of transcriptional …

Computational de novo drug design is a challenging issue in medicine, and it is desirable to
consider all of the relevant information of the biological systems in a disease state. Here, we …

Chemical-induced gene expression profiles provide critical information of chemicals in a
biological system, thus offering new opportunities for drug discovery. Despite their success …

Motivation Genome-wide identification of the transcriptomic responses of human cell lines to
drug treatments is a challenging issue in medical and pharmaceutical research. However …

Background The taxane cabazitaxel (CBZ) is a promising treatment for docetaxel-resistant
castration-resistant prostate cancer (CRPC). However, the survival benefit with CBZ for …

The aim of the present study was to demonstrate that ribavirin, a known inhibitor of eIF4E
and inosine 5'-phosphate dehydrogenase (IMPDH), also inhibits histone methyltransferase …