Rutin as a potent antioxidant: Implications for neurodegenerative disorders

AB Enogieru, W Haylett, DC Hiss… - Oxidative medicine …, 2018 - Wiley Online Library
A wide range of neurodegenerative diseases (NDs), including Alzheimer's disease,
Parkinson's disease, Huntington's disease, and prion diseases, share common mechanisms …

Chitosan oligosaccharide: Biological activities and potential therapeutic applications

C Muanprasat, V Chatsudthipong - Pharmacology & therapeutics, 2017 - Elsevier
Chitosan oligosaccharide (COS) is an oligomer of β-(1➔ 4)-linked d-glucosamine. COS can
be prepared from the deacetylation and hydrolysis of chitin, which is commonly found in the …

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

RA Linker, DH Lee, S Ryan, AM van Dam, R Conrad… - Brain, 2011 - academic.oup.com
Inflammation and oxidative stress are thought to promote tissue damage in multiple
sclerosis. Thus, novel therapeutics enhancing cellular resistance to free radicals could prove …

Oxidative stress in multiple sclerosis: Central and peripheral mode of action

K Ohl, K Tenbrock, M Kipp - Experimental neurology, 2016 - Elsevier
Accumulating evidence suggests that oxidative stress plays a major role in the pathogenesis
of multiple sclerosis (MS). Reactive oxygen species (ROS), which if produced in excess lead …

Melatonin rescue oxidative stress-mediated neuroinflammation/neurodegeneration and memory impairment in scopolamine-induced amnesia mice model

T Muhammad, T Ali, M Ikram, A Khan, SI Alam… - Journal of Neuroimmune …, 2019 - Springer
Cognitive decline and memory impairment induced by oxidative brain damage are the
critical pathological hallmarks of Alzheimer's disease (AD). Based on the potential …

Vanillic acid attenuates Aβ1-42-induced oxidative stress and cognitive impairment in mice

FU Amin, SA Shah, MO Kim - Scientific reports, 2017 - nature.com
Increasing evidence demonstrates that β-amyloid (Aβ) elicits oxidative stress, which
contributes to the pathogenesis and disease progression of Alzheimer's disease (AD). The …

Molecular cross-talk between the NRF2/KEAP1 signaling pathway, autophagy, and apoptosis

TM Stępkowski, MK Kruszewski - Free Radical Biology and Medicine, 2011 - Elsevier
Oxidative stress, perturbations in the cellular thiol level and redox balance, affects many
cellular functions, including signaling pathways. This, in turn, may cause the induction of …

Attenuation of Nrf2/Keap1/ARE in Alzheimer's disease by plant secondary metabolites: A mechanistic review

S Fakhri, M Pesce, A Patruno, SZ Moradi, A Iranpanah… - Molecules, 2020 - mdpi.com
Alzheimer's disease (AD) is a progressive neuronal/cognitional dysfunction, leading to
disability and death. Despite advances in revealing the pathophysiological mechanisms …

Alzheimer's disease: An overview of amyloid beta dependent pathogenesis and its therapeutic implications along with in silico approaches emphasizing the role of …

M Awasthi, S Singh, VP Pandey, UN Dwivedi - Journal of the neurological …, 2016 - Elsevier
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder
characterized by amyloid beta (Aβ) deposition in brain with subsequent formation of neuritic …

Effects of vanillic acid on Aβ1-40-induced oxidative stress and learning and memory deficit in male rats

N Ahmadi, S Safari, N Mirazi, SA Karimi, A Komaki - Brain research bulletin, 2021 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disease, in which the accumulation of β-
amyloid (Aβ) peptide in the extracellular space causes a progressive reduction in cognitive …