[HTML][HTML] Advances in spatial transcriptomics and related data analysis strategies

J Du, YC Yang, ZJ An, MH Zhang, XH Fu… - Journal of Translational …, 2023 - Springer
Spatial transcriptomics technologies developed in recent years can provide various
information including tissue heterogeneity, which is fundamental in biological and medical …

Melanoma and microbiota: Current understanding and future directions

B Routy, T Jackson, L Mählmann, CK Baumgartner… - Cancer cell, 2024 - cell.com
Over the last decade, the composition of the gut microbiota has been found to correlate with
the outcomes of cancer patients treated with immunotherapy. Accumulating evidence points …

[HTML][HTML] Spatial transcriptomics: recent developments and insights in respiratory research

WJ Wang, LX Chu, LY He, MJ Zhang, KT Dang… - Military Medical …, 2023 - Springer
The respiratory system's complex cellular heterogeneity presents unique challenges to
researchers in this field. Although bulk RNA sequencing and single-cell RNA sequencing …

[HTML][HTML] A review of spatial profiling technologies for characterizing the tumor microenvironment in immuno-oncology

B Hu, M Sajid, R Lv, L Liu, C Sun - Frontiers in Immunology, 2022 - frontiersin.org
Interpreting the mechanisms and principles that govern gene activity and how these genes
work according to-their cellular distribution in organisms has profound implications for …

Computational methods and challenges in analyzing intratumoral microbiome data

Q Wang, Z Liu, A Ma, Z Li, B Liu, Q Ma - Trends in microbiology, 2023 - cell.com
The human microbiome is intimately related to cancer biology and plays a vital role in the
efficacy of cancer treatments, including immunotherapy. Extraordinary evidence has …

Applying multi‐omics toward tumor microbiome research

N Zhang, S Kandalai, X Zhou, F Hossain, Q Zheng - iMeta, 2023 - Wiley Online Library
Rather than a “short‐term tenant,” the tumor microbiome has been shown to play a vital role
as a “permanent resident,” affecting carcinogenesis, cancer development, metastasis, and …

The intratumoral microbiota: friend or foe?

V Ferrari, M Rescigno - Trends in cancer, 2023 - cell.com
The intratumoral microbiota has been recently identified as important in cancer evasion
strategies. It can induce DNA damage, favor the epithelial–mesenchymal transition …

Intratumoral bacteria are an important “accomplice” in tumor development and metastasis

G Wang, X He, Q Wang - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
As emerging tumor components, intratumoral bacteria have been found in many solid
tumors. Several studies have demonstrated that different cancer subtypes have distinct …

[HTML][HTML] Microbiomes, their function, and cancer: how metatranscriptomics can close the knowledge gap

L Aitmanaitė, K Širmonaitis, G Russo - International journal of molecular …, 2023 - mdpi.com
The interaction between the microbial communities in the human body and the onset and
progression of cancer has not been investigated until recently. The vast majority of the …

Untangling the web of intratumor microbiota in lung cancer

W Liu, J Xu, Z Pi, Y Chen, G Jiang, Y Wan… - Biochimica et Biophysica …, 2023 - Elsevier
Microbes are pivotal in contemporary cancer research, influencing various biological
behaviors in cancer. The previous notion that the lung was sterile has been destabilized by …