Sensing and responding to changes in nutrient levels, including those of glucose, lipids, and
amino acids, by the body is necessary for survival. Accordingly, perturbations in nutrient …

Inflammatory bowel diseases (ulcerative colitis; Crohn's disease) are debilitating relapsing
inflammatory disorders affecting the gastrointestinal tract, with deleterious effect on quality of …

By human sensory analyses, we found that various extracellular calcium-sensing receptor
(CaSR) agonists enhance sweet, salty, and umami tastes, although they have no taste …

A low vitamin D status and inadequate calcium intake are important risk factors for various
types of cancer. Ecological studies using solar UV-B exposure as an index of vitamin D3 …

A novel calcium-binding peptide from bovine bone collagen hydrolysate was screened
based on a new target—the calcium-sensing receptor (CaSR), and its chelation mechanism …

Ca2+ is a universal second messenger controlling a wide variety of cellular reactions and
adaptive responses. The initial appreciation of Ca2+ as a universal signalling molecule was …

Type 2 diabetes (T2D) is a fast-increasing health problem globally, and it results from insulin
resistance and pancreatic β-cell dysfunction. The gastrointestinal (GI) tract is recognized as …

Background The extracellular calcium-sensing receptor (CaSR) is distributed throughout the
gastrointestinal tract, and its activation has been shown to promote intestinal homeostasis …

The extracellular calcium (Ca2+ o)-sensing receptor (CaSR) enables the parathyroid glands
and other CaSR-expressing cells involved in calcium homeostasis, such as the kidney and …

The extracellular calcium-sensing receptor (CaSR) is the first identified G protein–coupled
receptor to be activated by an ion, extracellular calcium (Ca2+). Since the identification of …