Adiponectin is the most abundant peptide secreted by adipocytes, whose reduction plays a
central role in obesity-related diseases, including insulin resistance/type 2 diabetes and …

Obesity-linked type 2 diabetes is one of the paramount causes of morbidity and mortality
worldwide, posing a major threat on human health, productivity, and quality of life. Despite …

Adipose tissue is now recognized as an important endocrine organ, capable of secreting a
large number of endocrine factors which regulate a wide variety of physiological functions …

Adenosine monophosphate‐activated protein kinase (AMPK) is a cellular energy sensor
activated during energy stress that plays a key role in maintaining energy homeostasis. This …

Maintaining proper energy balance in mammals entails intimate crosstalk between various
tissues and organs. These inter-organ communications are mediated, to a great extent, by …

Metformin has been used as a glucose lowering drug for several centuries and is now a first-
line drug for type 2 diabetes mellitus (T2DM). Since the discovery that it activates AMP …

Psoriasis is a chronic and immune-mediated skin condition characterized by pro-
inflammatory cytokines and keratinocyte hyperproliferation. Dendritic cells, T lymphocytes …

Abstract Liver kinase B1 (LKB1) has important roles in governing energy homeostasis by
regulating the activity of the energy sensor kinase AMP-activated protein kinase (AMPK) …

Studies of adipose tissue biology have demonstrated that adipose tissue should be
considered as both passive, energy-storing tissue and an endocrine organ because of the …

Diabetic kidney disease (DKD) is a major complication for diabetic patients. Adiponectin is
an insulin sensitizer and anti-inflammatory adipokine and is mainly secreted by adipocytes …