Epigenetics of dementia: understanding the disease as a transformation rather than a state
Alzheimer's disease and other idiopathic dementias are associated with epigenetic
transformations. These transformations connect the environment and genes to …
transformations. These transformations connect the environment and genes to …
The ETS family member GABPα modulates androgen receptor signalling and mediates an aggressive phenotype in prostate cancer
In prostate cancer (PC), the androgen receptor (AR) is a key transcription factor at all
disease stages, including the advanced stage of castrate-resistant prostate cancer (CRPC) …
disease stages, including the advanced stage of castrate-resistant prostate cancer (CRPC) …
Transcriptome-wide analysis of human liver reveals age-related differences in the expression of select functional gene clusters and evidence for a PPP1R10 …
T Schreiter, RK Gieseler, R Vílchez-Vargas, R Jauregui… - Pharmaceutics, 2021 - mdpi.com
A transcriptome-wide analysis of human liver for demonstrating differences between young
and old humans has not yet been performed. However, identifying major age-related …
and old humans has not yet been performed. However, identifying major age-related …
Identification of Transcripts with Shared Roles in the Pathogenesis of Postmenopausal Osteoporosis and Cardiovascular Disease
Epidemiological evidence suggests existing comorbidity between postmenopausal
osteoporosis (OP) and cardiovascular disease (CVD), but identification of possible shared …
osteoporosis (OP) and cardiovascular disease (CVD), but identification of possible shared …
Cistrome plasticity and mechanisms of cistrome reprogramming
I Garcia-Bassets, D Wang - Cell Cycle, 2012 - Taylor & Francis
Mammalian genomes contain thousands of cis-regulatory elements for each transcription
factor (TF), but TFs only occupy a relatively small subset referred to as cistrome. Recent …
factor (TF), but TFs only occupy a relatively small subset referred to as cistrome. Recent …
Computational assessment of transport distances in living skeletal muscle fibers studied in situ
Transport distances in skeletal muscle fibers are mitigated by these cells having multiple
nuclei. We have studied mouse living slow (soleus) and fast (extensor digitorum longus) …
nuclei. We have studied mouse living slow (soleus) and fast (extensor digitorum longus) …
The Impact of Trans-Regulation on the Evolutionary Rates of Metazoan Proteins
Transcription factor (TF) and microRNA (miRNA) are two crucial trans-regulatory factors that
coordinately control gene expression. Understanding the impacts of these two factors on the …
coordinately control gene expression. Understanding the impacts of these two factors on the …
Multi-scale modeling of gene regulatory networks via integration of temporal and topological biological data
G Dimitrakopoulos, K Sgarbas… - … Conference of the …, 2012 - ieeexplore.ieee.org
Regulome is the dynamic network representation of the regulatory interplay among genes,
proteins and other cellular components that control cellular processes. Reconstruction of …
proteins and other cellular components that control cellular processes. Reconstruction of …
(sfi)2 Statistics for Innovation – The experience of the Oslo centre in industrial statistics
A Frigessi, L Holden, A Teigland - Applied Stochastic Models in …, 2015 - Wiley Online Library
Statistics is one of the paramount sciences of the 21st century because of the emergence of
the value of data as a key asset for development. It is of fundamental importance to deliver …
the value of data as a key asset for development. It is of fundamental importance to deliver …
Integrative epigenome analysis
H Rydbeck - 2013 - duo.uio.no
High throughput technologies, like next generation sequencing, in combination with assays
for probing epigenetic marks, have made it possible to map the epigenetic landscapes of …
for probing epigenetic marks, have made it possible to map the epigenetic landscapes of …