Platelets have a crucial role in haemostasis and atherothrombosis. Pharmacological control
of platelet hyper-reactivity has become a cornerstone in the prevention of thrombo …

Despite years of encouraging translational research, ischemic stroke still remains as one of
the highest unmet medical needs nowadays, causing a tremendous burden to health care …

Background Antagonists of glycoprotein VI-triggered platelet activation used in combination
with recanalisation therapies are a promising therapeutic approach in acute ischaemic …

Platelets are essential for the formation of a haemostatic plug to prevent bleeding, while
neutrophils are the guardians of our immune defences against invading pathogens. The …

Antiplatelet therapy plays a critical role in the prevention and treatment of major
cardiovascular diseases triggered by thrombosis. Since the 1900s, significant progress in …

Platelets prevent blood loss during vascular injury and contribute to thrombus formation in
cardiovascular disease. Beyond these classical roles, platelets are critical for the host …

Abstract Background and Aims Glycoprotein VI (GPVI) is a platelet collagen/fibrin (ogen)
receptor and an emerging pharmacological target for the treatment of thrombotic and …

Distinct platelet activation patterns are elicited by the tyrosine kinase-linked collagen
receptor glycoprotein VI (GPVI) and the G-protein coupled protease-activated receptors …

A State of the Art lecture titled “Thrombus Composition and Thrombolysis Resistance in
Stroke” was presented at the ISTH Congress in 2022. Intravenous thrombolysis (IVT) …

BACKGROUND: Platelets play an important role in cardiovascular and cerebrovascular
diseases. Abdominal aortic aneurysm (AAA) is a highly lethal, atherosclerosis-related …