The mammalian circadian clock regulates day–night fluctuations in various physiological
processes. The circadian clock consists of the central clock in the suprachiasmatic nucleus …

Systems biology is a natural extension of molecular biology; it can be defined as biology
after identification of key gene (s). Systems-biological research is a multistage process …

Direct evidence for the requirement of delay in feedback repression in the mammalian
circadian clock has been elusive. Cryptochrome 1 (Cry1), an essential clock component …

A striking feature of the circadian clock is its flexible yet robust response to various
environmental conditions. To analyze the biochemical processes underlying this flexible-yet …

The effects of acute stress on the peripheral circadian system are not well understood in
vivo. Here, we show that sub-acute stress caused by restraint or social defeat potently …

The reduced sleep duration previously observed in Camk2b knockout mice revealed a role
for Ca2+/calmodulin-dependent protein kinase II (CaMKII) β as a sleep-promoting kinase …

Shift work or transmeridian travel can desynchronize the body's circadian rhythms from local
light–dark cycles. The mammalian suprachiasmatic nucleus (SCN) generates and entrains …

Background Mammalian circadian clocks control multiple physiological events. The principal
circadian clock generates seasonal variations in behavior as well. Seasonality elevates the …

Temperature compensation is a striking feature of the circadian clock. Here we investigate
biochemical mechanisms underlying temperature-compensated, CKIδ-dependent multi-site …

Aims: Circadian clock genes are involved in the development of drug-induced behaviors
and regulate neurotransmission pathways in addiction. Our aim was to study whether …