In contrast to solid cancers, which often require genetic modifications and complex cellular
reprogramming for effective metastatic dissemination, leukaemic cells uniquely possess the …

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. One of the major
clinical challenges is adequate diagnosis and treatment of central nervous system (CNS) …

Acute lymphoblastic leukaemia (ALL) has a marked propensity to metastasize to the central
nervous system (CNS). In contrast to brain metastases from solid tumours, metastases of …

T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% and 25% of total childhood
and adult ALL cases, respectively. During T-ALL, patients are at risk of organ infiltration by …

Long-term survival rates in childhood acute lymphoblastic leukemia (ALL) are currently
above 85% due to huge improvements in treatment. However, 15-20% of children still …

Metabolic reprogramming is a key hallmark of cancer, but less is known about metabolic
plasticity of the same tumor at different sites. Here, we investigated the metabolic adaptation …

Chimeric antigen receptor-T (CAR-T) cell therapy, as a novel cellular immunotherapy, has
dramatically reshaped the landscape of cancer treatment, especially in hematological …

Central nervous system (CNS) involvement by cytospin is associated with increased risk of
relapse in childhood acute lymphoblastic leukemia. We investigated if flow cytometric …

In acute lymphoblastic leukemia (ALL), central nervous system (CNS) involvement is a major
clinical concern. Despite nondetectable CNS leukemia in many cases, prophylactic CNS …

Simple Summary The recent emergence of targeted therapies, including antibody–drug
conjugates, bispecific antibodies, and CD19 chimeric antigen receptor (CAR) T cell therapy …