Rational design and experimental analysis of short-oligonucleotide substrate specificity for targeting bacterial nucleases

T Jiménez, J Botero, D Otaegui, J Calvo… - Journal of Medicinal …, 2021 - ACS Publications
An undecamer oligonucleotide probe based on a pair of deoxythymidines flanked by several
modified nucleotides is a specific and highly efficient biosensor for micrococcal nuclease …

Complex DNA Architectonics─ Self-Assembly of Amphiphilic Oligonucleotides into Ribbons, Vesicles, and Asterosomes

S Rothenbühler, I Iacovache… - Bioconjugate …, 2022 - ACS Publications
The precise arrangement of structural subunits is a key factor for the proper shape and
function of natural and artificial supramolecular assemblies. In DNA nanotechnology, the …

Tetraphenylethylene–DNA conjugates: influence of sticky ends and DNA sequence length on the supramolecular assembly of AIE-active vesicles

S Rothenbühler, A Gonzalez, I Iacovache… - Organic & …, 2022 - pubs.rsc.org
The supramolecular assembly of DNA conjugates, functionalized with tetraphenylethylene
(TPE) sticky ends, into vesicular structures is described. The aggregation-induced emission …

Polyamine–Oligonucleotide Conjugates: 2′-OMe-Triazole-Linked 1,4,7,10-Tetraazacyclododecane and Intercalating Dyes and Their Effect on the Thermal Stability …

MD Tomczyk, M Zalewski, PT Jørgensen, J Wengel… - Pharmaceutics, 2021 - mdpi.com
Oligonucleotides with the sequences 5′-GTG AUPA TGC, 5′-GCA TAUP CAC and 5′-
GUPG ATA UPGC, where UP is 2′-O-propargyl uridine, were subjected to post-synthetic …

Cross-linked DNA with carbazole pseudo-nucleoside enables potent inhibition of the cancer DNA-and RNA-mutating enzyme APOBEC3A

H Kurup, S Harjes, Y Su, T Hall, G Jameson, E Harjes… - 2023 - chemrxiv.org
The human antiviral enzyme APOBEC3A has mutagenic activity in many human cancers,
where it is used to fuel tumour evolution. Its single-stranded DNA and RNA C-to-U editing …

[引用][C] Rational Design and Experimental Analysis of Short-Oligonucleotide Substrate Specificity for Targeting Bacterial Nucleases

T Jiménez Trujillo, JA Botero Hincapié, D Otaegui Ansa… - 2021 - American Chemical Society