The oral microbiome: Role of key organisms and complex networks in oral health and disease

L Sedghi, V DiMassa, A Harrington… - Periodontology …, 2021 - Wiley Online Library
States of oral health and disease reflect the compositional and functional capacities of, as
well as the interspecies interactions within, the oral microbiota. The oral cavity exists as a …

[HTML][HTML] Periodontal disease: the good, the bad, and the unknown

LM Sedghi, M Bacino, YL Kapila - Frontiers in cellular and infection …, 2021 - frontiersin.org
Periodontal disease is classically characterized by progressive destruction of the soft and
hard tissues of the periodontal complex, mediated by an interplay between dysbiotic …

[HTML][HTML] The oralome and its dysbiosis: New insights into oral microbiome-host interactions

A Radaic, YL Kapila - Computational and structural biotechnology journal, 2021 - Elsevier
The oralome is the summary of the dynamic interactions orchestrated between the
ecological community of oral microorganisms (comprised of up to approximately 1000 …

Postbiotics and their health modulatory biomolecules

E Scott, K De Paepe, T Van de Wiele - Biomolecules, 2022 - mdpi.com
Postbiotics are a new category of biotics that have the potential to confer health benefits but,
unlike probiotics, do not require living cells to induce health effects and thus are not subject …

Periodontal disease–related nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: an emerging concept of oral‐liver axis

R Kuraji, S Sekino, Y Kapila, Y Numabe - Periodontology 2000, 2021 - Wiley Online Library
Periodontal disease, a chronic inflammatory disease of the periodontal tissues, is not only a
major cause of tooth loss, but it is also known to exacerbate/be associated with various …

Systemic antibiotics increase microbiota pathogenicity and oral bone loss

X Yuan, F Zhou, H Wang, X Xu, S Xu, C Zhang… - International Journal of …, 2023 - nature.com
Periodontitis is the most widespread oral disease and is closely related to the oral
microbiota. The oral microbiota is adversely affected by some pharmacologic treatments …

Bromelain and nisin: The natural antimicrobials with high potential in biomedicine

U Jančič, S Gorgieva - Pharmaceutics, 2021 - mdpi.com
Infectious diseases along with various cancer types are among the most significant public
health problems and the leading cause of death worldwide. The situation has become even …

Paradigm shift in the pathogenesis and treatment of oral cancer and other cancers focused on the oralome and antimicrobial‐based therapeutics

A Radaic, S Ganther, P Kamarajan… - Periodontology …, 2021 - Wiley Online Library
The oral microbiome is a community of microorganisms, comprised of bacteria, fungi,
viruses, archaea, and protozoa, that form a complex ecosystem within the oral cavity …

How probiotics, prebiotics, synbiotics, and postbiotics prevent dental caries: An oral microbiota perspective

SC Luo, SM Wei, XT Luo, QQ Yang, KH Wong… - npj Biofilms and …, 2024 - nature.com
Dental caries, a highly prevalent oral disease, impacts a significant portion of the global
population. Conventional approaches that indiscriminately eradicate microbes disrupt the …

Nisin a probiotic bacteriocin mitigates brain microbiome dysbiosis and Alzheimer's disease-like neuroinflammation triggered by periodontal disease

C Zhao, R Kuraji, C Ye, L Gao, A Radaic… - Journal of …, 2023 - Springer
Introduction Periodontitis-related oral microbial dysbiosis is thought to contribute to
Alzheimer's disease (AD) neuroinflammation and brain amyloid production. Since probiotics …