The traffic of the different types of immune cells is an important aspect in the immune
response. Chemokines are soluble peptides that are able to attract cells by interaction with …

Chronic inflammation is a risk factor for several gastrointestinal malignancies, including
colorectal cancer. Recent epidemiological studies and clinical trials demonstrate that long …

A large body of evidence indicates that chronic inflammation is one of several key risk
factors for cancer initiation, progression, and metastasis. However, the underlying …

Background As accessible diagnostic approaches fail to differentiate between ulcerative
colitis (UC) and Crohn's colitis (CC) in one-third of patients with predominantly colonic …

Paneth cells (PCs), a specialized secretory cell type in the small intestine, are increasingly
recognized as having an essential role in host responses to microbiome and environmental …

CXCL1 is a CXC chemokine, CXCR2 ligand and chemotactic factor for neutrophils. In this
paper, we present a review of the role of the chemokine CXCL1 in physiology and in …

Background Aberrant gene expression in the gut mucosa might contribute to the initiation
and progression of Crohn's disease (CD). RNA sequencing (RNA-seq) provides precise …

Chemokines were originally defined as cytokines that affect the movement of immune cells.
In recent years, due to the increasing importance of immune cells in the tumor …

Background Ulcerative colitis (UC) presents diagnostic and therapeutic difficulties. The
primary objective of this study is to identify efficacious biomarkers for diagnosis and …

Chemokines are best known for their classic leukocyte chemotactic activity, which is critical
for directing the immune response to sites of infection and injury. However, recent studies …