TBX3, a member of the ancient and evolutionary conserved T-box transcription factor family,
is a critical developmental regulator of several structures including the heart, mammary …

Congenital heart disease (CHD) is the most common type of birth defect. The advent of
corrective cardiac surgery and the increase in knowledge concerning the longitudinal care …

Although kidney parenchymal tissue can be generated in vitro, reconstructing the complex
vasculature of the kidney remains a daunting task. The molecular pathways that specify and …

Cell proliferation is tightly controlled by inhibitors that block cell cycle progression until
growth signals relieve this inhibition, allowing cells to divide. In several tissues, including the …

Dun is a wild-type coat color in horses characterized by pigment dilution with a striking
pattern of dark areas termed primitive markings. Here we show that pigment dilution in Dun …

All epithelial components of the inner ear, including sensory hair cells and innervating
afferent neurons, arise by patterning and differentiation of epithelial progenitors residing in a …

BCL9 and PYGO are β-catenin cofactors that enhance the transcription of Wnt target genes.
They have been proposed as therapeutic targets to diminish Wnt signaling output in …

Cellular senescence is a crucial tumor suppressor mechanism. We discovered a
CAPERα/TBX3 repressor complex required to prevent senescence in primary cells and …

Numerous signals drive the proliferative expansion of the distal endoderm and the
underlying mesenchyme during lung branching morphogenesis, but little is known about …

Pluripotency represents a cell state comprising a fine-tuned pattern of transcription factor
activity required for embryonic stem cell (ESC) self-renewal. TBX3 is the earliest expressed …