Pd-catalyzed regioselective activation of C (sp 2)–H and C (sp 3)–H bonds

W Ali, GA Oliver, DB Werz, D Maiti - Chemical Society Reviews, 2024 - pubs.rsc.org
Differentiating between two highly similar C–H bonds in a given molecule remains a
fundamental challenge in synthetic organic chemistry. Directing group assisted strategies for …

Palladium‐Catalyzed Remote C− H Functionalization: Non‐Covalent Interactions and Reversibly Bound Templates

AT Sebastian, S Maji, M Rajashekhar… - Angewandte Chemie …, 2024 - Wiley Online Library
Pd‐catalysis has stood as a pivotal force in synthetic transformations for decades,
maintaining its status as a paramount tool in the realm of C− H bond activation. While …

Ligand-modulated nickel-catalyzed regioselective silylalkylation of alkenes

C Ding, Y Ren, Y Yu, G Yin - Nature Communications, 2023 - nature.com
Organosilicon compounds have shown tremendous potential in drug discovery and their
synthesis stimulates wide interest. Multicomponent cross-coupling of alkenes with silicon …

Forked Vein Structure W/WO3−x with Dual Active Sites in W and Oxygen Vacancies to Enhance Methylene Self‐Coupling for Efficient Conversion of Methane to …

H Li, Z Sun, C Lei, W Kang, L Ma, Q Shen, H Jia, J Xue… - Small, 2024 - Wiley Online Library
The directional conversion of methane to ethylene is challenging due to the dissociation of
the C─ H bond and the self‐coupling of methyl intermediates. Herein, a novel W/WO3− x …

Substrate NOBINAc ligand affinity for Pd II-catalyzed enantioselective C–H activation over reactive β-C–H bonds in ferrocenyl amines

D Parganiha, RA Thorat, AD Dhumale… - Chemical …, 2025 - pubs.rsc.org
Ferrocenyl amines as directing groups for C–H activation have limitations as they are prone
to undergo oxidation, allylic deamination, and β-hydride elimination. The fundamental …

Overcoming limitations in non-activated alkene cross-coupling with nickel catalysis and anionic ligands

D Wu, W Kong, Y Bao, C Huang, W Liu, Y Li, G Yin - Nature Catalysis, 2024 - nature.com
Multicomponent cross-coupling reactions involving alkenes represent a compelling strategy
for accessing three-dimensional molecules, a key pursuit in contemporary medicinal …

Metal-Free C(sp3)–H Bond Arylation of 3-Methylindole Derivatives via 3-Indole Imine Methides

J Wang, R Yu, C Nian, M Liao, Z Han, J Sun… - Organic …, 2023 - ACS Publications
Direct arylation of the benzylic C (sp3)–H bond is one of the most straightforward strategies
for the construction of multi-aryl methanes, owing to the extraordinary step and atom …

Cobalt-Catalyzed Cascade C–H Activation/Annulation Polymerizations toward Diversified and Multifunctional Sulfur-Containing Fused Heterocyclic Polymers

D Fan, D Wang, J Zhang, X Fu, X Yan… - Journal of the …, 2024 - ACS Publications
Transition-metal-catalyzed C–H activation has greatly benefited the synthesis and
development of functional polymer materials, and the construction of multifunctional fused …

Efficient Construction of β-Arylethylamines via Selective C(sp3)-H Arylation of Aliphatic Amines

H Tu, X Deng, H Li, Y Xu, J Chen, X Zhang, W Su - ACS Catalysis, 2024 - ACS Publications
The synthetic innovations in generating β-arylethylamines have the potential to propel
advancements in drug discovery, as β-arylethylamines are common structural motifs in …

Synthesis of Chiral Saturated Heterocycles Bearing Quaternary Centers via Enantioselective β-C(sp3)–H Activation of Lactams

P Lu, WR Burgenson, BJ Simmons, S Liu… - Journal of the …, 2025 - ACS Publications
The development of catalytic methods for the synthesis of enantiopure saturated
heterocycles has been a long-standing challenge in asymmetric catalysis. We describe the …