Viral infections during pregnancy are associated with significant adverse perinatal and fetal
outcomes. Pregnancy is a unique immunologic and physiologic state, which can influence …

The contribution of placental immune responses to congenital Zika virus (ZIKV) syndrome
remains poorly understood. Here, we leveraged a mouse model of ZIKV infection to identify …

SARS-CoV-2 infection during pregnancy is associated with severe COVID-19 and adverse
fetal outcomes, but the underlying mechanisms remain poorly understood. Moreover, clinical …

Type III interferons (IFN-λ) are antiviral and immunomodulatory cytokines that have been
best characterized in respiratory and gastrointestinal infections, but the effects of IFN-λ …

Lambda interferons (IFNLs) provide critical host defense against pathogens encountered at
mucosal surfaces. In humans, IFNL signaling is regulated in part by low and cell‐type …

Zika virus (ZIKV) is unusual among flaviviruses in its ability to spread between humans
through sexual contact, as well as by mosquitoes. Sexual transmission has the potential to …

Zika virus (ZIKV) is a mosquito-borne Flavivirus that persistently infects patients; enters
protected brain, placental, and testicular compartments; is sexually transmitted; and causes …

Zika virus (ZIKV) infections during pregnancy can result in Congenital Zika Syndrome (CZS),
a range of severe neurological outcomes in fetuses that primarily occur during early …

Human interferon (IFN) lambda (IFNL, IFN-L or IFN-λ) locus has several functional genetic
variants but their role in regulating in vivo gene expression, and whether they associate with …

Immune regulation at the maternal-fetal interface is complex due to conflicting
immunological objectives: protection of the fetus from maternal pathogens, and prevention of …