Dietary Phytochemicals as Potential Chemopreventive Agents against Tobacco-Induced Lung Carcinogenesis

Y Ding, R Hou, J Yu, C Xing, C Zhuang, Z Qu - Nutrients, 2023 - mdpi.com
Lung cancer is the second most common cancer in the world. Cigarette smoking is strongly
connected with lung cancer. Benzo [a] pyrene (BaP) and 4-(N-methyl-N-nitrosamine)-1-(3 …

Butyrate drives metabolic rewiring and epigenetic reprogramming in human colon cancer cells

L Wang, AAF Shannar, R Wu, P Chou… - Molecular nutrition & …, 2022 - Wiley Online Library
Scope Butyrate (B) is a short‐chain fatty acid produced by dietary fiber, known to inhibit
histone deacetylases (HDACs) and possess cancer‐preventive/anticancer effects. However …

Garlic‐derived compounds: Epigenetic modulators and their antitumor effects

H Zhang, H Wang, L Qin, S Lin - Phytotherapy Research, 2024 - Wiley Online Library
Cancer is a highly heterogeneous disease that poses a serious threat to human health
worldwide. Despite significant advances in the diagnosis and treatment of cancer, the …

Histone deacetylase inhibitor belinostat regulates metabolic reprogramming in killing KRAS‐mutant human lung cancer cells

RM Peter, MS Sarwar, SZ Mostafa… - Molecular …, 2023 - Wiley Online Library
Kirsten rat sarcoma virus (KRAS) oncogene, found in 20%–25% of lung cancer patients,
potentially regulates metabolic reprogramming and redox status during tumorigenesis …

[HTML][HTML] Circular RNA circNIPBL regulates TP53-H179R mutations in NNK-induced bronchial epithelial carcinogenesis

Y Liu, S Fang, T Lin, W Chen, Y Chen, Y Wang… - Environment …, 2024 - Elsevier
Exposure to environmental carcinogens is a significant contributor to cancer development,
with genetic and epigenetic alterations playing pivotal roles in the carcinogenic process …

An update on potential molecular biomarkers of dietary phytochemicals targeting lung cancer interception and prevention

RM Peter, PJ Chou, A Shannar, K Patel, Y Pan… - Pharmaceutical …, 2023 - Springer
Since ancient times, dietary phytochemicals are known for their medicinal properties. They
are broadly classified into polyphenols, terpenoids, alkaloids, phytosterols, and organosulfur …

The environmental carcinogen benzo [a] pyrene regulates epigenetic reprogramming and metabolic rewiring in a two-stage mouse skin carcinogenesis model

MS Sarwar, CN Ramirez, HC Dina Kuo, P Chou… - …, 2023 - academic.oup.com
Non-melanoma skin cancer (NMSC) is the most common cancer in the world. Environmental
exposure to carcinogens is one of the major causes of NMSC initiation and progression. In …

Suppressing the activation of protein kinase A as a DNA damage-independent mechanistic lead for dihydromethysticin prophylaxis of NNK-induced lung …

T Bian, H Ding, Y Wang, Q Hu, S Chen… - …, 2022 - academic.oup.com
Our earlier work demonstrated varying potency of dihydromethysticin (DHM) as the active
kava phytochemical for prophylaxis of tobacco carcinogen nicotine-derived nitrosamine …

[HTML][HTML] A New Frontier in Studying Dietary Phytochemicals in Cancer and in Health: Metabolic and Epigenetic Reprogramming

A Shannar, MS Sarwar, ANT Kong - Preventive Nutrition and Food …, 2022 - ncbi.nlm.nih.gov
Metabolic rewiring and epigenetic reprogramming are closely inter-related, and mutually
regulate each other to control cell growth in cancer initiation, promotion, progression, and …

Metabolomic, DNA methylomic, and transcriptomic profiling of suberoylanilide hydroxamic acid effects on lps-exposed lung epithelial cells

PJ Chou, MS Sarwar, L Wang, R Wu, S Li… - Cancer Prevention …, 2023 - AACR
Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase (HDAC) inhibitor with
anticancer effects via epigenetic and non-epigenetic mechanisms. The role of SAHA in …