Hair is a primary characteristic of mammals, and exerts a wide range of functions including
thermoregulation, physical protection, sensory activity, and social interactions. The hair shaft …

Hair follicle morphogenesis depends on Wnt, Shh, Notch, BMP and other signaling
pathways interplay between epithelial and mesenchymal cells. The Wnt pathway plays an …

More than 150 genes have been identified that affect skin color either directly or indirectly,
and we review current understanding of physiological factors that regulate skin …

Everyone knows and seems to agree that melanocytes are there to generate melanin–an
intriguing, but underestimated multipurpose molecule that is capable of doing far more than …

A central goal of regenerative medicine is to generate transplantable organs from cells
derived or expanded in vitro. Although numerous studies have demonstrated the production …

Adult stem cells reside in specialized niches where they receive environmental cues to
maintain tissue homeostasis. In mammals, the stem cell niche within hair follicles is home to …

The forkhead transcription factor Foxn1 is indispensable for thymus development, but the
mechanisms by which it mediates thymic epithelial cell (TEC) development are poorly …

β-Catenin signaling is required for hair follicle development, but it is unknown whether its
activation is sufficient to globally program embryonic epidermis to hair follicle fate. To …

Pigment patterns in the integument have long-attracted attention from both scientists and
non-scientists alike since their natural attractiveness combines with their excellence as …

The thymus provides multiple microenvironments that are essential for the development and
repertoire selection of T lymphocytes. The thymic cortex induces the generation and positive …