Transposable elements (TEs) are insertional mutagens that contribute greatly to the
plasticity of eukaryotic genomes, influencing the evolution and adaptation of species as well …

Autoantibodies specific for idiopathic inflammatory myopathy (myositis-specific
autoantibodies (MSAs)) are clinically useful biomarkers to help the diagnosis of …

Tumours use various strategies to evade immune surveillance,. Immunotherapies targeting
tumour immune evasion such as immune checkpoint blockade have shown considerable …

The addressable pocket of a protein is often not functionally relevant in disease. This is true
for the multidomain, bromodomain-containing transcriptional regulator TRIM24. TRIM24 has …

The life cycle of endogenous retroviruses (ERVs), also called long terminal repeat (LTR)
retrotransposons, begins with transcription by RNA polymerase II followed by reverse …

Tripartite motif (TRIM) proteins have been implicated in multiple cellular functions, including
antiviral activity. Research efforts so far indicate that the antiviral activity of TRIMs relies, for …

Noncoding RNAs (ncRNAs) are classes of transcripts that are encoded by the genome and
transcribed but never get translated into proteins. Though not translated into proteins …

Despite often being classified as selfish or junk DNA, transposable elements (TEs) are a
group of abundant genetic sequences that have a significant impact on mammalian …

Mammalian genomes have accumulated millions of retrotransposed sequences during
evolution. This material can be divided into long terminal repeat (LTR) retrotransposons that …

The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77
members known in the human, most of which consist of a RING-finger domain, one or two B …