The most fundamental feature of cellular form is size, which sets the scale of all cell
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …

Though cell size varies between different cells and across species, the nuclear-to-
cytoplasmic (N/C) ratio is largely maintained across species and within cell types. A cell …

Cell size is tightly controlled in healthy tissues, but it is unclear how deviations in cell size
affect cell physiology. To address this, we measured how the cell's proteome changes with …

Innate lymphoid cells (ILCs) can quickly switch from a quiescent state to an active state and
rapidly produce effector molecules that provide critical early immune protection. How the …

A fundamental feature of cellular growth is that total protein and RNA amounts increase with
cell size to keep concentrations approximately constant. A key component of this is that …

RNA concentration homeostasis involves coordinating RNA abundance and synthesis rates
with cell size. Here, we study this in human cells by combining genome-wide perturbations …

For most genes, mRNA transcript abundance scales with cell size to ensure a constant
concentration. Scaling of mRNA synthesis rates with cell size plays an important role, with …

Motivation Gene expression is characterized by stochastic bursts of transcription that occur
at brief and random periods of promoter activity. The kinetics of gene expression burstiness …

Depending on cell type, environmental inputs, and disease, the cells in the human body can
have widely different sizes. In recent years, it has become clear that cell size is a major …

Intracellular reaction rates depend on concentrations and hence their levels are often
regulated. However classical models of stochastic gene expression lack a cell size …