Increasing evidence demonstrates that neuroplasticity, a fundamental mechanism of
neuronal adaptation, is disrupted in mood disorders and in animal models of stress. Here we …

Ursolic acid (UA) is a pentacyclic triterpene which is found in common herbs and medicinal
plants that are reputed for a variety of pharmacological effects. Both as an active principle of …

Glutamate neurotransmission was recently implicated in the action of stress and in
antidepressant mechanisms. We report that chronic (not acute) treatment with three …

BACKGROUND: Postpartum depression (PPD) affects approximately 10% to 20% of women
during the first 4 weeks of the postpartum period and is characterized by labile mood with …

The physical and functional interactions between serotonin–glutamate and serotonin–
dopamine signaling have been suggested to be involved in psychosis pathophysiology and …

Introduction Dysfunction at various levels of the somatosensory system can lead to ocular
surface pain with a neuropathic component. Compared to nociceptive pain (due to noxious …

Recently there is increasing concern over the association between sleep deprivation (S-
Dep) and depression. Mounting evidence suggests that S-Dep might be a risk factor for …

Selective serotonin reuptake inhibitors (SSRIs) are the most widely prescribed drugs for
mood disorders. While the mechanism of SSRI action is still unknown, SSRIs are thought to …

Growing evidence suggests a pivotal role for glutamatergic neurotransmission in the
pathophysiology of major depressive disorder and in the action of antidepressants. The …

Background: Expression of the neuronal membrane glycoprotein M6a (GPM6A), the
proteolipid protein (PLP/DM20) family member, is downregulated in the hippocampus of …