The IL-17 family of cytokines has emerged over the last two decades as a pleiotropic group
of molecules that function in a wide variety of both beneficial and detrimental (pathological) …

Only a handful of the more than 100,000 fungal species on our planet cause disease in
humans, yet the number of life-threatening fungal infections in patients has recently …

Death from sepsis in the neonatal period remains a serious threat for millions. Within 3 days
of administration, bacille Calmette-Guérin (BCG) vaccination can reduce mortality from …

Mice with defective IL‐17 immunity display a broad vulnerability to various infectious agents
at diverse mucocutaneous surfaces. In humans, the study of patients with various primary …

The fungus Cryptococcus is a major cause of meningoencephalitis in HIV-infected as well as
HIV-uninfected individuals with mortalities in developed countries of 20% and 30 …

Understanding the host immune response during cryptococcal meningitis (CM) is of critical
importance for the development of immunomodulatory therapies. We profiled the …

Cryptococcosis is caused by the fungal genus Cryptococcus. Cryptococcosis, predominantly
meningoencephalitis, emerged with the HIV pandemic, primarily afflicting HIV-infected …

Background. Correlates of immune protection in patients with human immunodeficiency
virus (HIV)–associated cryptococcal meningitis are poorly defined. A clearer understanding …

The vast majority of infection with cryptococcal species occurs with Cryptococcus
neoformans in the severely immunocompromised. A significant exception to this is the …

Th17 cells are increasingly being recognized as an important T helper subset for immune-
mediated protection, especially against pathogens at mucosal ports of entry. In several …