Protein and peptide therapeutics require parenteral administration, which can be a deterrent
to medication adherence. For this reason, there have been extensive efforts to develop …

Drugs are typically small molecules that are generally classified as xenobiotics, which are
foreign to the human body. Several endogenous molecules, however, such as steroids and …

The human breast cancer resistance protein (BCRP/ABCG2) is an ATP-binding cassette
efflux transporter that uses ATP hydrolysis to expel xenobiotics from cells, including anti …

RNA-mediated drugs are a rapidly growing class of therapeutics. Over the last five years, the
list of FDA-approved RNA therapeutics has expanded owing to their unique targets and …

Simple Summary Colorectal cancer (CRC) causes a high number (more than 800,000) of
deaths worldwide each year. Better methods for early diagnosis and the development of …

There is a growing interest among people in western countries for adoption of healthier
lifestyle habits and diet behaviors with one of the most known ones to be Mediterranean diet …

Prophylactic voriconazole use is recommended for children undergoing hematopoietic cell
transplantation (HCT). Dosing considerations are essential, due to the narrow therapeutic …

In this study, we aimed to elucidate biopharmaceutical characteristics of the anti-ulcer drug
rebamipide, with special emphasis on the influence of gastrointestinal (GI) mucus on …

To predict the outcome of intestinal drug transporter induction on pharmacokinetics,
signaling of the DNA message along with messenger RNA (mRNA) transcription and protein …

Wistar and Sprague Dawley are the most common strains of rat used in pharmaceutical
research and are used interchangeably in pre-clinical drug development. No studies have …