Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

Functional status is considered the main determinant of healthy aging. Impairment in
skeletal muscle and the cardiovascular system, two interrelated systems, results in …

The 70-kDa heat shock proteins (Hsp70s) are ubiquitous molecular chaperones that act in a
large variety of cellular protein folding and remodelling processes. They function virtually at …

Frailty, a consequence of the interaction of the aging process and certain chronic diseases,
compromises functional outcomes in the elderly and substantially increases their risk for …

Physical exercise represents a major challenge to whole-body homeostasis, provoking
acute and adaptative responses at the cellular and systemic levels. Different sources of …

Probiotics have shown potential to counteract sarcopenia, although the extent to which they
can influence domains of sarcopenia such as muscle mass and strength in humans is …

Oxidative stress plays a key role in the aging process. Lifestyle behaviours including low
physical activity and inadequate nutritional habits in addition to genetic susceptibility and …

Declines in both physical and cognitive function are associated with increasing age.
Understanding the physiological link between physical frailty and cognitive decline may …

Oxidative damage is one mechanism linking aging with chronic diseases including the
progressive loss of skeletal muscle mass and function called sarcopenia. Thus, mitigating …

Liver fibrosis is a common pathological process of end-stage liver diseases. However, the
role of microRNA (miRNA) in liver fibrosis is poorly understood. The activated hepatic …