Chronic liver diseases such as nonalcoholic fatty liver disease (NAFLD) or viral hepatitis are
characterized by persistent inflammation and subsequent liver fibrosis. Liver fibrosis critically …

Inflammation is one of the most characteristic features of chronic liver disease of viral,
alcoholic, fatty, and autoimmune origin. Inflammation is typically present in all disease …

Sustained hepatic inflammation is an important factor in progression of chronic liver
diseases, including hepatitis C or non-alcoholic steatohepatitis. Liver inflammation is …

Hepatic stellate cells are resident perisinusoidal cells distributed throughout the liver, with a
remarkable range of functions in normal and injured liver. Derived embryologically from …

Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of
death in patients with chronic liver disease. Chronic liver injury of virtually any etiology …

Multiple etiologies of liver disease lead to liver fibrosis through integrated signaling networks
that regulate the deposition of extracellular matrix. This cascade of responses drives the …

The hepatic stellate cell has surprised and engaged physiologists, pathologists, and
hepatologists for over 130 years, yet clear evidence of its role in hepatic injury and fibrosis …

Substantial improvements in the treatment of chronic liver disease have accelerated interest
in uncovering the mechanisms underlying hepatic fibrosis and its resolution. Activation of …

Chronic liver inflammation drives hepatic fibrosis, and current immunosuppressive, anti-
inflammatory, and anti-viral therapies can weaken this driver. Hepatic fibrosis is reversed …

Liver fibrosis is defined as excessive extracellular matrix deposition and is based on
complex interactions between matrix-producing hepatic stellate cells and an abundance of …