Triple‐negative breast cancer (TNBC) is a subgroup of 15%‐20% of diagnosed breast
cancer patients. It is generally considered to be the most difficult breast cancer subtype to …

Currently, cancer ranks as the second leading cause of death worldwide, and at the same
time, the burden of cancer continues to increase. The underlying molecular pathways …

The Notch signalling pathway is a highly conserved developmental signalling pathway, with
vital roles in determining cell fate during embryonic development and tissue homeostasis …

Background Radiotherapy is a conventional and effective local treatment for breast cancer.
However, residual or recurrent tumors appears frequently because of radioresistance. Novel …

Triple-negative breast cancer (TNBC) is an aggressive cancer subtype for which effective
therapies are lacking. Epidermal growth factor receptor (EGFR) is overexpressed in various …

Hypoxia is a feature of most solid tumours and predicts for poor prognosis. In radiobiological
hypoxia (< 0.1% O2) cells become up to three times more resistant to radiation. The …

Elevated expression of Copine 1 (CPNE1) has been observed in multiple cancers; however,
the underlying mechanisms by which it affects cancer cells are unclear. We aimed to study …

TRIB3, a pseudokinase, was previously studied within only some specific cancer types,
leaving its comprehensive functions in pan-cancer contexts largely unexplored. Here, we …

Abstract Background Tribbles pseudokinase 3 (TRIB3) protein is a pseudokinase which
plays an important role in cellular stress, metabolism, and tumor progression. However, the …

Simple Summary Tribbles pseudokinases represent a sub-branch of the CAMK
(Ca2+/calmodulin-dependent protein kinase) subfamily and are associated with disease …