Marine natural products

AR Carroll, BR Copp, RA Davis, RA Keyzers… - Natural product …, 2021 - pubs.rsc.org
This review covers the literature published in 2019 for marine natural products (MNPs), with
719 citations (701 for the period January to December 2019) referring to compounds …

Meroterpenoid natural products from Streptomyces bacteria–the evolution of chemoenzymatic syntheses

LAM Murray, SMK McKinnie, BS Moore… - Natural product …, 2020 - pubs.rsc.org
Covering: Up to January 2020 Meroterpenoids derived from the polyketide 1, 3, 6, 8-
tetrahydroxynaphthalene (THN) are complex natural products produced exclusively by …

Biomimetic dearomatization strategies in the total synthesis of meroterpenoid natural products

JH George - Accounts of Chemical Research, 2021 - ACS Publications
Conspectus Natural products are biosynthesized from a limited pool of starting materials via
pathways that obey the same chemical logic as textbook organic reactions. Given the …

Halogenases for biosynthetic pathway engineering: Toward new routes to naturals and non-naturals

BRK Menon, D Richmond, N Menon - Catalysis Reviews, 2022 - Taylor & Francis
Nature's repertoire of bio-halogenase enzymes is intriguing with halogenases from various
natural product biosynthetic clusters that carry out site and region-specific halogenation of …

Enantioselective total synthesis of hyperforin and pyrohyperforin

Y Ji, B Hong, I Franzoni, M Wang… - Angewandte Chemie …, 2022 - Wiley Online Library
Capitalizing on the late‐stage diversification of an essential 1, 3‐diene intermediate, we
describe herein a 9‐step enantioselective total synthesis of (+)‐hyperforin and (+) …

Recent progress in the synthesis of limonoids and limonoid-like natural products

S Fu, B Liu - Organic Chemistry Frontiers, 2020 - pubs.rsc.org
Limonoid and limonoid-like natural products have demonstrated diverse bioactive properties
and attracted considerable synthetic efforts. They provide a good platform to examine the …

Cobalt-Bisoxazoline-Catalyzed Enantioselective Cross-Coupling of α-Bromo Esters with Alkenyl Grignard Reagents

Y Zhou, L Wang, G Yuan, S Liu, X Sun, C Yuan… - Organic …, 2020 - ACS Publications
The first catalytic asymmetric Kumada cross-coupling of organic halides with alkenyl
Grignard reagents has been developed. The reaction was promoted by the cobalt …

Biomimetic total synthesis of the rubiginosin meroterpenoids

L Burchill, AJ Day, O Yahiaoui, JH George - Organic Letters, 2020 - ACS Publications
Total synthesis of the Rhododendron meroterpenoids rubiginosins A and G, which both
contain unusual 6–6–6–4 ring systems, has been achieved using a bioinspired cascade …

Recent advances in oxa-6π electrocyclization reactivity for the synthesis of privileged natural product scaffolds

SP Roche - Organics, 2021 - mdpi.com
The stunning advances in understanding the reactivity and selectivity principles of
asymmetric pericyclic reactions have had a profound impact on the synthetic planning of …

Synthetic approaches to cis-THC, a promising scaffold in medicinal chemistry

L Gurgone, A La-Venia, D Caprioglio… - Frontiers in Natural …, 2023 - frontiersin.org
The chemistry of phytocannabinoids has witnessed renewed interest these last decades as
a consequence of reduced restrictions, research on the endocannabinoid system and the …