Recent strategies in the synthesis of spiroindole and spirooxindole scaffolds

S Nasri, M Bayat, F Mirzaei - Topics in Current Chemistry, 2021 - Springer
Spiroindole and spirooxindole scaffolds are very important spiro-heterocyclic compounds in
drug design processes. Significant attention has been directed at obtaining molecules …

Applications of novel composite UiO-66-NH 2/Melamine with phosphorous acid tags as a porous and efficient catalyst for the preparation of novel spiro-oxindoles

E Tavakoli, H Sepehrmansourie, M Zarei… - New Journal of …, 2022 - pubs.rsc.org
In this study, we introduce a novel approach for incorporating phosphorus acid tags into a
UiO-66-NH2/Melamine-based metal–organic framework (MOF). The structure and …

1, 3-dipolar cycloaddition reactions of isatin-derived azomethine ylides for the synthesis of spirooxindole and indole-derived scaffolds: Recent developments

FR Miankooshki, M Bayat, S Nasri, NH Samet - Molecular Diversity, 2023 - Springer
The unique therapeutic and biological characteristics of spirooxindole have led to the
presentation of numerous reactions for the synthesis of spirooxindoles through 1, 3-Dipolar …

Substrate-controlled regioselectivity switchable [3+ 2] annulations to access spirooxindole skeletons

KK Wang, YL Li, R Chen, ZY Wang, NB Li… - The Journal of …, 2022 - ACS Publications
The additive-free [3+ 2] annulation from isatins, amino acids with 2-styrylbenzoxazoles, was
described, providing a series of functional and structurally complex 3, 3′-pyrrolidinyl …

A Sulfonic Acid Polyvinyl Pyridinium Ionic Liquid Catalyzes the Multi-Component Synthesis of Spiro-indoline-3,5′-pyrano[2,3-d]-pyrimidines and -Pyrazines

M Khalaj, M Taherkhani, L Payen, A Klein - Molecules, 2023 - mdpi.com
A sulfonated poly-4-vinyl pyridinium (PVPy-IL-B-SO3H) containing an acidic
pyridinium/HSO3− ionic liquid moiety was prepared and used as a catalyst for the three …

Synthesis of Zr-MOF/rGO-nanocomposites used for spirooxindole scaffolds derivatives

G Kumar, A Dutta, M Goswami, B Meena… - Journal of Molecular …, 2023 - Elsevier
A highly resourceful synthetic strategy has been developed for the production of
spirooxindole derivatives employing Zr-MOF/rGO nanocomposites as a heterogeneous …

Synthesis and Application of Task-Specific Bimetal–Organic Frameworks in the Synthesis of Biological Active Spiro-Oxindoles

E Tavakoli, H Sepehrmansourie, MA Zolfigol… - Inorganic …, 2024 - ACS Publications
The use of click chemistry as a smart and suitable method for the development of new
heterogeneous catalysts is based on metal–organic frameworks as well as the production of …

Synthesis of novel γ-butyrolactone-based phenazine compounds via microwave-assisted multicomponent domino reactions

HT Nguyen, PH Thi, G Le-Nhat-Thuy, QGN Thi… - Chemistry of …, 2022 - Springer
A series of new and significative γ-butyrolactone-based phenazines were synthesized
through two-step one-pot five-component reactions of 2-hydroxy-1, 4-naphthoquinone, a …

[3+ 2]-Annulation of oxindolinyl-malononitriles with Morita–Baylis–Hillman acetates of nitroalkenes for the regio-and diastereoselective synthesis of spirocyclopentane …

A Pareek, ST Sivanandan, S Bhagat, INN Namboothiri - Tetrahedron, 2022 - Elsevier
Oxindolinyl-malononitrile participates as a 1, 2-binucleophile in a highly regio-and
stereoselective [3+ 2] annulation with 1, 3-bielectrophilic nitroallylic acetates leading to …

Regioselective synthesis of spirooxindole-pyrolidine via (GAP) chemistry process: Experimental and DFT study

F Mataji, L Youseftabar-Miri, MJ Javan… - Journal of Molecular …, 2022 - Elsevier
A series of the some spirooxindole-pyrrolidine derivatives were synthesized via 1, 3-dipolar
cycloadditions of isatin,(E)-2-oxoindolino-3-ylidene acetophenones and, primary/secondly …