Sense and nonsense from a systems biology approach to microbial recombinant protein production
YR Sevastsyanovich, SN Alfasi… - … and applied biochemistry, 2010 - Wiley Online Library
The 'Holy Grail'of recombinant protein production remains the availability of generic
protocols and hosts for the production of even the most difficult target products. The present …
protocols and hosts for the production of even the most difficult target products. The present …
Functional Expression of Horseradish Peroxidase in E.coli by Directed Evolution
In an effort to develop a bacterial expression system for horseradish peroxidase (HRP), we
inserted the gene encoding HRP into the pET‐22b (+) vector (Novagen) as a fusion to the …
inserted the gene encoding HRP into the pET‐22b (+) vector (Novagen) as a fusion to the …
Molecular mechanism of host specificity in Plasmodium falciparum infection: role of circumsporozoite protein
D Rathore, SCL Hrstka, JB Sacci, P De la Vega… - Journal of Biological …, 2003 - ASBMB
Plasmodium falciparum sporozoites invade liver cells in humans and set the stage for
malaria infection. Circumsporozoite protein (CSP), a predominant surface antigen on …
malaria infection. Circumsporozoite protein (CSP), a predominant surface antigen on …
Inclusion of a furin-sensitive spacer enhances the cytotoxicity of ribotoxin restrictocin containing recombinant single-chain immunotoxins
A Goyal, JK Batra - Biochemical Journal, 2000 - portlandpress.com
Chimaeric toxins have considerable therapeutic potential to treat various malignancies. We
have previously used the fungal ribonucleolytic toxin restrictocin to make chimaeric toxins in …
have previously used the fungal ribonucleolytic toxin restrictocin to make chimaeric toxins in …
Regio-and enantioselective alkane hydroxylation with modified cytochrome P450
FH Arnold, MW Peters, P Meinhold - US Patent 7,524,664, 2009 - Google Patents
2004-10-27 Assigned to CALIFORNIA INSTITUTE OF TECHNOLOGY reassignment
CALIFORNIA INSTITUTE OF TECHNOLOGY ASSIGNMENT OF ASSIGNORS INTEREST …
CALIFORNIA INSTITUTE OF TECHNOLOGY ASSIGNMENT OF ASSIGNORS INTEREST …
A bispecific enediyne-energized fusion protein containing ligand-based and antibody-based oligopeptides against epidermal growth factor receptor and human …
X Guo, X Zhu, Y Shang, S Zhang, Y Zhen - Clinical cancer research, 2010 - AACR
Purpose: The cooverexpression of epidermal growth factor receptor (EGFR) and human
epidermal growth factor receptor 2 (HER2) observed in many human tumors and their …
epidermal growth factor receptor 2 (HER2) observed in many human tumors and their …
Tuftsin-based, EGFR-targeting fusion protein and its enediyne-energized analog show high antitumor efficacy associated with CD47 down-regulation
WJ Liu, XJ Liu, L Li, Y Li, SH Zhang… - Cancer Immunology …, 2014 - Springer
Tuftsin (TF) is an immunomodulator tetrapeptide (Thr-Lys-Pro-Arg) that binds to the receptor
neuropilin-1 (Nrp1) on the surface of cells. Many reports have described anti-tumor activity of …
neuropilin-1 (Nrp1) on the surface of cells. Many reports have described anti-tumor activity of …
Thermostable peroxide-driven cytochrome P450 oxygenase variants and methods of use
The invention relates to novel variants of cytochrome P450 oxygenases. These variants
have at least one mutation improving their ability to use peroxide as an oxygen donor as …
have at least one mutation improving their ability to use peroxide as an oxygen donor as …
Overproduction of human granulocyte-colony stimulating factor fused to the PelB signal peptide in Escherichia coli
BH Chung, MJ Sohn, SW Oh, US Park, H Poo… - Journal of fermentation …, 1998 - Elsevier
In an attempt to induce the secretion of human granulocyte-colony stimulating factor (hG-
CSF) in Escherichia coli, the gene encoding mature hG-CSF was fused to the gene for the …
CSF) in Escherichia coli, the gene encoding mature hG-CSF was fused to the gene for the …
Peroxide-driven cytochrome P450 oxygenase variants
The invention relates to novel variants of cytochrome P450 oxygenases. These variants
have an improved ability to use peroxide as an oxygen donor as compared to the …
have an improved ability to use peroxide as an oxygen donor as compared to the …