Water is an essential participant in the stability, structure, dynamics, and function of proteins
and other biomolecules. Thermodynamically, changes in the aqueous environment affect …

When Szent-Györgyi called water the “matrix of life”, 1 he was echoing an old sentiment.
Paracelsus in the 16th century said that “water was the matrix of the world and of all its …

Dynamic biological measurements require low light levels to avoid damaging the specimen.
With this constraint on optical power, quantum noise fundamentally limits the measurement …

The stability of proteins in aqueous solution is routinely enhanced by cosolvents such as
glycerol. Glycerol is known to shift the native protein ensemble to more compact states …

Protein functions require conformational motions. We show here that the dominant
conformational motions are slaved by the hydration shell and the bulk solvent. The protein …

Antifreeze proteins (AFPs) are specific proteins that are able to lower the freezing point of
aqueous solutions relative to the melting point. Hyperactive AFPs, identified in insects, have …

Protein surface hydration is fundamental to its structure and activity. We report here the
direct mapping of global hydration dynamics around a protein in its native and molten …

Energy flows anisotropically through the residues and vibrational states of globular proteins.
A variety of experimental and computational studies have identified energy transport …

Biomolecular dynamics and stability are predominantly investigated in vitro and extrapolated
to explain function in the living cell. We present fast relaxation imaging (FreI), which …

Viscoelastic subdiffusion: generalized Langevin equation approach Page 195 VISCOELASTIC
SUBDIFFUSION: GENERALIZED LANGEVIN EQUATION APPROACH IGOR GOYCHUK …