MicroRNA as an important target for anticancer drug development

Z Fu, L Wang, S Li, F Chen, KKW Au-Yeung… - Frontiers in …, 2021 - frontiersin.org
Cancer has become the second greatest cause of death worldwide. Although there are
several different classes of anticancer drugs that are available in clinic, some tough issues …

Dysregulation of microRNAs in breast cancer and their potential role as prognostic and predictive biomarkers in patient management

E van Schooneveld, H Wildiers, I Vergote… - Breast cancer …, 2015 - Springer
MicroRNAs (miRNAs) are an emerging class of gene expression modulators with relevant
roles in several biological processes, including cell differentiation, development, apoptosis …

MiR-375 reduces the stemness of gastric cancer cells through triggering ferroptosis

H Ni, H Qin, C Sun, Y Liu, G Ruan, Q Guo, T Xi… - Stem cell research & …, 2021 - Springer
Background Gastric cancer stem cells (CSCs) are the main causes of metastasis and drug
resistance. We previously indicated that miR-375 can inhibit Helicobacter pylori-induced …

[HTML][HTML] Targeting oncomiRNAs and mimicking tumor suppressor miRNAs: Νew trends in the development of miRNA therapeutic strategies in oncology

R Gambari, E Brognara… - … journal of oncology, 2016 - spandidos-publications.com
MicroRNA (miRNA or miR) therapeutics in cancer are based on targeting or mimicking
miRNAs involved in cancer onset, progression, angiogenesis, epithelial-mesenchymal …

miR-375 is involved in Hippo pathway by targeting YAP1/TEAD4-CTGF axis in gastric carcinogenesis

W Kang, T Huang, Y Zhou, J Zhang, RWM Lung… - Cell death & …, 2018 - nature.com
Abstract miR-375 is a tumor-suppressive microRNA (miRNA) in gastric cancer (GC).
However, its molecular mechanism remains unclear. The aim of this study is to …

Molecular mechanisms of epithelial to mesenchymal transition in tumor metastasis

A Nieszporek, K Skrzypek, G Adamek… - Acta Biochimica …, 2019 - ruj.uj.edu.pl
Epithelial to mesenchymal transition (EMT) is a process where cancer cells lose their
epithelial features, the cytoskeletal architecture is re-organized, the cell shape changes and …

[HTML][HTML] Circulating microRNAs and long non-coding RNAs in gastric cancer diagnosis: an update and review

YK Huang, JC Yu - World journal of gastroenterology: WJG, 2015 - ncbi.nlm.nih.gov
Gastric cancer (GC) is the fourth most common cancer and the third leading cause of cancer
mortality worldwide. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are the …

Potential diagnostic, prognostic and therapeutic targets of microRNAs in human gastric cancer

MM Tsai, CS Wang, CY Tsai, HW Huang… - International journal of …, 2016 - mdpi.com
Human gastric cancer (GC) is characterized by a high incidence and mortality rate, largely
because it is normally not identified until a relatively advanced stage owing to a lack of early …

MicroRNA expression profiles in gastric carcinogenesis

J Hwang, BH Min, J Jang, SY Kang, H Bae, SS Jang… - Scientific reports, 2018 - nature.com
Intestinal-type gastric carcinoma exhibits a multistep carcinogenic sequence from adenoma
to carcinoma with a gradual increase in genomic alterations. But the roles of microRNAs …

Circ‐SERPINE2 promotes the development of gastric carcinoma by sponging miR‐375 and modulating YWHAZ

J Liu, S Song, S Lin, M Zhang, Y Du, D Zhang… - Cell …, 2019 - Wiley Online Library
Abstract Objectives Circular RNAs (circRNAs) exist extensively in the eukaryotic genome.
The study aimed to identify the role of hsa_circ_0008365 (Circ‐SERPINE2) in gastric …