Peru–Progress in health and sciences in 200 years of independence

RM Carrillo-Larco, WC Guzman-Vilca… - The Lancet Regional …, 2022 - thelancet.com
Peru celebrates 200 years of independence in 2021. Over this period of independent life,
and despite the turbulent socio-political scenarios, from internal armed conflict to economic …

A review of ancestrality and admixture in Latin America and the caribbean focusing on native American and African descendant populations

TC De Oliveira, R Secolin, I Lopes-Cendes - Frontiers in Genetics, 2023 - frontiersin.org
Genomics can reveal essential features about the demographic evolution of a population
that may not be apparent from historical elements. In recent years, there has been a …

Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample

MS Naslavsky, CK Suemoto, LA Brito, MO Scliar… - Molecular …, 2022 - nature.com
Dementia is more prevalent in Blacks than in Whites, likely due to a combination of
environmental and biological factors. Paradoxically, clinical studies suggest an attenuation …

Whole-genome sequencing of 1,171 elderly admixed individuals from Brazil

MS Naslavsky, MO Scliar, GL Yamamoto… - Nature …, 2022 - nature.com
As whole-genome sequencing (WGS) becomes the gold standard tool for studying
population genomics and medical applications, data on diverse non-European and admixed …

Climate and demography drive 7000 years of dietary change in the Central Andes

KM Wilson, WC McCool, SC Brewer… - Scientific Reports, 2022 - nature.com
Explaining the factors that influence past dietary variation is critically important for
understanding changes in subsistence, health, and status in past societies; yet systematic …

Clotting factor genes are associated with preeclampsia in high-altitude pregnant women in the Peruvian Andes

MA Nieves-Colón, KMB Rivera, K Sandoval… - The American Journal of …, 2022 - cell.com
Preeclampsia is a multi-organ complication of pregnancy characterized by sudden
hypertension and proteinuria that is among the leading causes of preterm delivery and …

Uncovering signals of positive selection in Peruvian populations from three ecological regions

R Caro-Consuegra, MA Nieves-Colón… - Molecular biology …, 2022 - academic.oup.com
Peru hosts extremely diverse ecosystems which can be broadly classified into the following
three major ecoregions: the Pacific desert coast, the Andean highlands, and the Amazon …

Indigenous people from Amazon show genetic signatures of pathogen-driven selection

CM Couto-Silva, K Nunes, G Venturini… - Science …, 2023 - science.org
Ecological conditions in the Amazon rainforests are historically favorable for the
transmission of numerous tropical diseases, especially vector-borne diseases. The high …

Natural selection of immune and metabolic genes associated with health in two lowland Bolivian populations

AJ Lea, A Garcia, J Arevalo… - Proceedings of the …, 2023 - National Acad Sciences
A growing body of work has addressed human adaptations to diverse environments using
genomic data, but few studies have connected putatively selected alleles to phenotypes …

Adipose development is consistent across hunter–gatherers and diverges from western references

JV Hackman, BC Campbell… - … of the Royal …, 2024 - royalsocietypublishing.org
Despite agreement that humans have evolved to be unusually fat primates, adipose
patterning among hunter–gatherers has received little empirical consideration. Here we …