Cells must adapt to changes in their environment to maintain cell, tissue and organismal
integrity in the face of mechanical, chemical or microbiological stress. Nuclear factor-κB (NF …

Rheumatoid arthritis (RA) is the most common systemic inflammatory rheumatic disease. It is
associated with significant burden at the patient and societal level. Extensive efforts have …

Carbon quantum dots (CQDs) have emerged as promising materials for optoelectronic
applications on account of carbon's intrinsic merits of high stability, low cost, and …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-
associated variants with diverse genomic and biological data sets to provide insight into …

Systemic autoinflammatory diseases are driven by abnormal activation of innate immunity.
Herein we describe a new disease caused by high-penetrance heterozygous germline …

The Pathogenesis of Rheumatoid Arthritis | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …

Study of the genetics of rheumatoid arthritis (RA) began about four decades ago with the
discovery of HLA-DRB1. Since the beginning of this century, a number of non-HLA risk loci …

Rheumatoid arthritis is a chronic autoinflammatory disease that affects 1–2% of the world's
population and is characterized by widespread joint inflammation. Interleukin-1 is an …

To identify new genetic risk factors for rheumatoid arthritis, we conducted a genome-wide
association study meta-analysis of 5,539 autoantibody-positive individuals with rheumatoid …

We performed a second-generation genome-wide association study of 4,533 individuals
with celiac disease (cases) and 10,750 control subjects. We genotyped 113 selected SNPs …