Assessment of spiramycin-loaded chitosan nanoparticles treatment on acute and chronic toxoplasmosis in mice

SE Etewa, DAA El-Maaty, RS Hamza… - Journal of parasitic …, 2018 - Springer
Toxoplasmosis is a zoonotic parasitic disease with worldwide distribution. Chitosan is a
natural polymer which is commonly used in the production of nanomedicines. It is known to …

Effect of spiramycin versus aminoguanidine and their combined use in experimental toxoplasmosis

M Omar, BE Abaza, E Mousa, SM Ibrahim… - Journal of Parasitic …, 2021 - Springer
Toxoplasmosis is one of the widest spread parasitic infections which is caused by
Toxoplasma gondii protozoon. Many experimental studies have evaluated the effect of …

Oxidative stress and DNA damage in horses naturally infected with Theileria equi

M Radakovic, D Davitkov, S Borozan, S Stojanovic… - The Veterinary …, 2016 - Elsevier
The aim of this study was to determine the concentrations of oxidative stress parameters and
DNA damage in horses infected by Theileria equi. Initial screening of 110 horses with …

The effect of Nigella sativa oil-and wheat germ oil-loaded metal organic frameworks on chronic murine toxoplasmosis

OS Mohammad, HM El Naggar, HF Abdelmaksoud… - Acta Tropica, 2023 - Elsevier
Abstract Treatment of chronic toxoplasmosis is challenging as the available drugs are
effective only in the acute stage. Therefore, the current study aimed to investigate Nigella …

Ginger is a potential therapeutic for chronic toxoplasmosis

AM El-Kady, WAI Al-Megrin, IAM Abdel-Rahman… - Pathogens, 2022 - mdpi.com
Background: Toxoplasma gondii (T. gondii) is an opportunistic parasite that causes serious
diseases in humans, particularly immunocompromised individuals and pregnant women. To …

Novel insights on the therapeutic effect of levamisole on the chronic toxoplasmosis in mice model

HS Zoghroban, BM Elmansory, YA Issa… - Experimental …, 2023 - Elsevier
Latent toxoplasmosis mostly reactivates which could result in acute encephalitis. Chronic
toxoplasmosis treatments are severely constrained by Toxoplasma cyst resistance. Novel …

Mefloquine loaded niosomes as a promising approach for the treatment of acute and chronic toxoplasmosis

BM El Sharazly, IAA Asaad, NA Yassen… - Acta tropica, 2023 - Elsevier
Toxoplasmosis is a disease with a worldwide distribution and significant morbidity and
mortality. In search of effective treatment, mefloquine (MQ) was repurposed and loaded with …

In vivo effect of anti-TNF agent (etanercept) in reactivation of latent toxoplasmosis

NM El-Sayed, KA Ismail, AF Badawy… - Journal of Parasitic …, 2016 - Springer
Abstract Toxoplasma gondii (T. gondii), an intracellular parasite, establishes a chronic
infection by forming cysts preferentially in the brain. TNF-α plays an important role in …

DNA double-strand breaks in the Toxoplasma gondii-infected cells by the action of reactive oxygen species

H Zhuang, C Yao, X Zhao, X Chen, Y Yang, S Huang… - Parasites & …, 2020 - Springer
Background Toxoplasma gondii is an obligate parasite of all warm-blooded animals around
the globe. Once infecting a cell, it manipulates the host's DNA damage response that is yet …

Characterization of the parasite-induced lesions in the posterior segment of the eye

NM El-Sayed, EH Safar - Indian journal of ophthalmology, 2015 - journals.lww.com
Ocular lesions are frequently associated with different parasitic infections. The classes of
infection include protozoa, nematodes, cestodes, and ectoparasites. Ocular parasitic …