Copper-containing enzymes perform fundamental functions by activating dioxygen (O 2) and
therefore allowing chemical energy-transfer for aerobic metabolism. The copper …

Astrocytes are known to influence neuronal activity through different mechanisms, including
the homeostatic control of extracellular levels of ions and neurotransmitters and the …

Astrocytic Ca2+ signaling has been intensively studied in health and disease but has not
been quantified during natural sleep. Here, we employ an activity-based algorithm to assess …

Non-rapid eye movement (NREM) sleep, characterized by slow-wave electrophysiological
activity, underlies several critical functions, including learning and memory. However, NREM …

Microglial control of activity‐dependent plasticity and synaptic remodeling in neuronal
networks has been the subject of intense research in the past several years. Although …

Alzheimer's disease (AD) is the major cause of dementia, characterized by the presence of
amyloid-beta plaques and neurofibrillary tau tangles. Plaques and tangles are associated …

Neuronal signalling is a key element in neuronal communication and is essential for the
proper functioning of the CNS. Astrocytes, the most prominent glia in the brain play a key …

Cerebral small vessel disease (CSVD) is a leading cause of cognitive decline in elderly
people and development of Alzheimer's disease (AD). Blood–brain barrier (BBB) leakage is …

Sleep abnormalities are widely reported in patients with Alzheimer's disease (AD) and are
linked to cognitive impairments. Sleep abnormalities could be potential biomarkers to detect …

Astrocytes are fundamental building blocks of the central nervous system. Their dysfunction
has been implicated in many psychiatric disorders, including alcohol use disorder, yet our …