Recent studies of nitrogen containing heterocyclic compounds as novel antiviral agents: A review

A Mermer, T Keles, Y Sirin - Bioorganic Chemistry, 2021 - Elsevier
N-heterocycles are important, not only because of their abundance, but above all because of
their chemical, biological and technical significance. They play an important role in …

Recent progress in biologically active indole hybrids: A mini review

E Mahmoud, AM Hayallah, S Kovacic… - Pharmacological …, 2022 - Springer
The indole moiety is one of the most widespread heterocycles found in both natural products
and biological systems. Indoles have important biological activities including anticancer …

Synthesis and biological activity of new indole based derivatives as potent anticancer, antioxidant and antimicrobial agents

M Konus, D Çetin, ND Kızılkan, C Yılmaz… - Journal of Molecular …, 2022 - Elsevier
Indoles have very critical roles to design new biologically active molecules in medicinal
chemistry. They display higher biological activities or create new biological properties when …

[HTML][HTML] 2-methylindole analogs as cholinesterases and glutathione S-transferase inhibitors: Synthesis, biological evaluation, molecular docking, and pharmacokinetic …

A Cetin, E Bursal, F Türkan - Arabian Journal of Chemistry, 2021 - Elsevier
In this study, we aimed to (i) synthesize new 2-methylindole analogs containing various
amino structures, pyrrolidine, piperidine, morpholine, and substituted phenyl groups through …

Thiophene‐containing compounds with antimicrobial activity

G Roman - Archiv der Pharmazie, 2022 - Wiley Online Library
Thiophene, as a member of the group of five‐membered heterocycles containing one
heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the …

[HTML][HTML] Synthesis and antifungal activities of novel trifluoroethane derivatives with coumarin, indole and thiophene

B Zhou, X Yuan, L Fan, Z Pan, X Chang, S Jiang… - Journal of Saudi …, 2022 - Elsevier
A series of novel 1-(β-coumarinyl)-1-(β-indolyl)-1-(α-thiophenyl) trifluoroethane derivatives
5aaa-5hdb were prepared by one-pot reaction from 3-(trifluoroacetyl) coumarin with indole …

Indole/isatin‐containing hybrids as potential antibacterial agents

F Song, Z Li, Y Bian, X Huo, J Fang… - Archiv der …, 2020 - Wiley Online Library
The emergence and worldwide spread of drug‐resistant bacteria have already posed a
serious threat to human life, creating the urgent need to develop potent and novel …

Synthesis, design, and assessment of novel morpholine-derived Mannich bases as multifunctional agents for the potential enzyme inhibitory properties including …

S Boy, F Türkan, M Beytur, A Aras, O Akyıldırım… - Bioorganic …, 2021 - Elsevier
Abstract The synthesized Schiff Bases were reacted with formaldehyde and secondary
amine such as 2, 6-dimethylmorpholine to afford N-Mannich bases through the Mannich …

Synthesis of water soluble symmetric and asymmetric pillar [5] arene derivatives: Cytotoxicity, apoptosis and molecular docking studies

R Liman, AN Kursunlu, M Ozmen, S Arslan… - Journal of Molecular …, 2022 - Elsevier
In this study, two water-soluble pillar [5] arenes,[1-(3-(trimethyl-azane) propoxy)-4-
methoxyhydro-chloridepillar [5] arene (asym-P5) and 1, 4-bis (2-(trimethyl-azane) ethoxy) …

Optical, electrochemical and DFT studies of donor-acceptor typed indole derivatives

BB Carbas, HA Noori, E Kavak, Y Kaya… - Journal of Molecular …, 2023 - Elsevier
The donor-acceptor type indole chromophore motif presents an interesting molecular
architecture to the scientific world, unfortunately, as in every special and beautiful formation …