RNA is a key regulator of almost every cellular process, and the structures adopted by RNA
molecules are thought to be central to their functions. The recent fast-paced evolution of high …

The zoonotic emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
and the ensuing coronavirus disease 2019 (COVID-19) pandemic have profoundly affected …

The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

RNA can fold back on itself to adopt a wide range of structures. These range from relatively
simple hairpins to intricate 3D folds and can be accompanied by regulatory interactions with …

The main protease (Mpro) of SARS-CoV-2 is essential for viral replication and has been the
focus of many drug discovery efforts since the start of the COVID-19 pandemic. Nirmatrelvir …

The RNA genome of SARS-CoV-2 contains a frameshift stimulatory element (FSE) that
allows access to an alternative reading frame through− 1 programmed ribosomal …

Proteolysis targeting chimera (PROTAC) degradation of pathogenic proteins by hijacking of
the ubiquitin-proteasome-system has become a promising strategy in drug design. The …

As CASP15 participants, in the new category of 3D RNA structure prediction, we applied
expert modeling with the support of our proprietary system RNAComposer. Although …

Coronaviruses are a group of related RNA viruses that cause respiratory diseases in
humans and animals. Understanding the mechanisms of translation regulation during …

Nucleocapsid protein (N-protein) is required for multiple steps in betacoronaviruses
replication. SARS-CoV-2-N-protein condenses with specific viral RNAs at particular …