Background Mechanical ventilation is an essential therapy to support critically ill respiratory
failure patients. Current standards of care consist of generalised approaches, such as the …

Clinical decision-making is based on knowledge, expertise, and authority, with clinicians
approving almost every intervention—the starting point for delivery of “All the right care, but …

Mechanical ventilation (MV) is a core therapy in the intensive care unit (ICU). Some patients
rely on MV to support breathing. However, it is a difficult therapy to optimise, where inter-and …

Computerized decision support (CDS) is the most advanced form of clinical decision support
available and has evolved with innovative technologies to provide meaningful assistance to …

Objectives: To evaluate the physiologic effects of applying advice on mechanical ventilation
by an open-loop, physiologic model–based clinical decision support system. Design …

This dissertation has addressed the broad hypothesis as to whether building mathematical
models is useful as a tool for translating physiological knowledge into clinical practice. In …

Our education system seems to fail to enable clinicians to broadly understand core
physiological principles. The emphasis on reductionist science, including “omics” branches …

Management of mechanical ventilation in intensive care patients is complicated by
conflicting clinical goals. Decision support systems (DSS) may support clinicians in finding …

Clinical decisions related to noninvasive respiratory support (NIRS) for acute respiratory
failure patients are complex. NIRS strategies have favorable benefits for patients when …

Ventilatory support, while life saving, can also cause or aggravate lung injury through
several mechanisms which are encompassed within ventilator-associated lung injury (VALI) …