The chaperonins are ubiquitous and essential nanomachines that assist in protein folding in
an ATP-driven manner. They consist of two back-to-back stacked oligomeric rings with …

Axons are the narrow, up-to-meter long cellular processes of neurons that form the
biological cables wiring our nervous system. Most axons must survive for an organism's …

Tubulin folding cofactors (TFCs) are required for tubulin folding, α/β tubulin heterodimer
formation, and microtubule (MT) dynamics in yeast and mammals. However, the functions of …

Colchicine has been used to treat gout and, more recently, to effectively prevent
autoinflammatory diseases and both primary and recurrent episodes of pericarditis. The anti …

Tubulin proteostasis is regulated by a group of molecular chaperones termed tubulin
cofactors (TBC). Whereas tubulin heterodimer formation is well‐characterized biochemically …

Cullin 7 is the 'scaffold'of the cullin-RING-based E3 ligases which catalyze the final step of
the ubiquitination cascade in eukaryotic organisms. Although one study has reported the …

Foetal alcohol spectrum disorders (FASDs) are a spectrum of neurological disorders whose
neurological symptoms, besides the neuronal damage caused by alcohol, may also be …

Although end-binding protein 1 (EB1) is well known to regulate microtubule dynamics, the
role of EB1 in apoptosis of non-small cell lung cancer (NSCLC) is poorly understood. Here …

Simple Summary Peripheral blood analyses can offer a minimally invasive view into
systemic immunity during cancer and can lead to the identification of biomarkers for cancer …

Human PIWIL2, aka HILI, is a member of PIWI protein family and overexpresses in various
tumors. However, the underlying mechanisms of HILI in tumorigenesis remain largely …