Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Traumatic brain injury (TBI) remains one of the most fatal and debilitating conditions in the
world. Current clinical management in severe TBI patients is mainly concerned with …

Purpose Contemporary trauma resuscitation prioritizes control of bleeding and uses major
haemorrhage protocols (MHPs) to prevent and treat coagulopathy. We aimed to determine …

Trauma can affect any individual at any location and at any time over a lifespan. The
disruption of macrobarriers and microbarriers induces instant activation of innate immunity …

Background Severe traumatic injury continues to present challenges to healthcare systems
around the world, and post-traumatic bleeding remains a leading cause of potentially …

Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …

Traumatic spinal cord injury is a devastating insult followed by progressive cord atrophy and
neurodegeneration. Dysregulated or non-resolving inflammatory processes can disturb …

Rotational thromboelastometry (ROTEM) is a point-of-care viscoelastic method and enables
to assess viscoelastic profiles of whole blood in various clinical settings. ROTEM-guided …

Executive summary A concerted effort to tackle the global health problem posed by traumatic
brain injury (TBI) is long overdue. TBI is a public health challenge of vast, but insufficiently …

Background Major haemorrhage is a clinical emergency that results in morbidity and
mortality: practice guidance is important to reduce these risks. Delayed recognition of …