Abstract Background The Nuclear Factor kappaB (NF-kB) family consists of transcription
factors that play a complex and essential role in the regulation of immune responses and …

Human papillomaviruses (HPVs), which are small, double-stranded, circular DNA viruses
infecting human epithelial cells, are associated with various benign and malignant lesions of …

Many cancer therapies aim to trigger apoptosis in cancer cells. Nevertheless, the presence
of oncogenic alterations in these cells and distorted composition of tumour …

For decades, radiotherapy and chemotherapy were the two only approaches exploiting DNA
repair processes to fight against cancer. Nowadays, cancer therapeutics can be a major …

Nuclear factor kappa B (NF-κB) is a pluripotent and crucial dimer transcription factor that
orchestrates various physiological and pathological processes, especially cell proliferation …

Abstract The Human Papillomavirus (HPV) E1 protein is the only viral protein with enzymatic
activity. The main known function of this protein is the regulation of the viral DNA replication …

Papillomaviruses induce a range of benign and malignant lesions in their hosts, including
cervical cancer, that is associated with high-risk human papillomavirus (HPV) types. The …

To clarify E1^ E4's role during high-risk HPV infection, the E4 proteins of HPV16 and 18
were compared side by side using an isogenic keratinocyte differentiation model. While no …

The DDR consists of multiple pathways that sense, signal, and respond to anomalous DNA.
To promote efficient replication, viruses have evolved to engage and even modulate the …

Human papillomaviruses (HPVs) are non‐enveloped double‐stranded DNA viruses. When
HPV infection persists, infected tissues can develop many HPV‐related diseases such as …