Neurodegenerative disorders are characterized by extensive neuron death that leads to
functional decline, but the neurobiological correlates of functional decline in normal aging …

Life's Journey If life is indeed a journey, then poetry must be the map that reveals all its
topographic possibilities… while science is the compass that keeps us from getting lost.—RT …

We examined age-related changes in object and spatial visual processing in two separate
experiments. Regional cerebral blood flow (rCBF) was measured in young and old subjects …

It was believed that the cause of the cognitive decline exhibited by human and non-human
primates during normal aging was a loss of cortical neurons. It is now known that significant …

Abstract [This book] presents the insights of more than 3 decades of empirical research on
the neural processes by which memory is formed, stored, and retrieved. Fuster focuses …

Age-associated memory impairment (AAMI) occurs in many mammalian species, including
humans. In contrast to Alzheimer's disease (AD), in which circuit disruption occurs through …

Background and rationale Reinstatement of the function of working memory, the cardinal
cognitive process essential for human reasoning and judgment, is potentially the most …

To date, a therapy for Huntington's disease (HD), a genetic, neurodegenerative disorder,
remains elusive. HD is characterized by cell loss in the basal ganglia, with particular …

Alterations in inhibitory interneurons contribute to cognitive deficits associated with several
psychiatric and neurological diseases. Phasic and tonic inhibition imparted by γ …

That the human frontal lobes are particularly vulnerable to age-related deterioration has
been frequently invoked as an explanation of functional decline in aging. This “frontal aging …