The placental barrier: the gate and the fate in drug distribution

N Tetro, S Moushaev, M Rubinchik-Stern… - Pharmaceutical …, 2018 - Springer
Optimal development of the embryo and the fetus depends on placental passage of gases,
nutrients, hormones, and waste products. These molecules are transferred across the …

Placental control of drug delivery

S Al-Enazy, S Ali, N Albekairi, M El-Tawil… - Advanced drug delivery …, 2017 - Elsevier
The placenta serves as the interface between the maternal and fetal circulations and
regulates the transfer of oxygen, nutrients, and waste products. When exogenous …

Engineering of stepwise-targeting chitosan oligosaccharide conjugate for the treatment of acute kidney injury

DW Wang, SJ Li, XY Tan, JH Wang, Y Hu, Z Tan… - Carbohydrate …, 2021 - Elsevier
Acute kidney injury (AKI) is a common and serious clinical syndrome of acute renal
dysfunction in a short period. One of therapeutic interventions for AKI is to reduce ROS …

Novel blood test for early biomarkers of preeclampsia and Alzheimer's disease

S Cheng, S Banerjee, LA Daiello, A Nakashima… - Scientific reports, 2021 - nature.com
A non-invasive and sensitive blood test has long been a goal for early stage disease
diagnosis and treatment for Alzheimer's disease (AD) and other proteinopathy diseases. We …

Endocytosis in the placenta: An undervalued mediator of placental transfer

LDF Cooke, DA Tumbarello, NC Harvey, JK Sethi… - Placenta, 2021 - Elsevier
Endocytosis is an essential mechanism for cellular uptake in many human tissues. A range
of endocytic mechanisms occur including clathrin-dependent and-independent …

Megalin-targeting liposomes for placental drug delivery

AA Alfaifi, RS Heyder, ER Bielski, RM Almuqbil… - Journal of Controlled …, 2020 - Elsevier
Every year, complications during pregnancy affect more than 26 million women. Some of
those diseases are associated with significant morbidity and mortality, as is the case of …

[HTML][HTML] Vitamin D status and its association with parathyroid hormone in 23,134 outpatients

X Chen, C Chu, C Doebis, Y Xiong, Y Cao… - The Journal of Steroid …, 2022 - Elsevier
Highlights•25 (OH) D and iPTH were inversely correlated across sex and different stages of
age in outpatients with normal kidney function.•The correlation of 25 (OH) D and iPTH was …

Renal-targeting triptolide-glucosamine conjugate exhibits lower toxicity and superior efficacy in attenuation of ischemia/reperfusion renal injury in rats

Y Fu, Q Lin, T Gong, X Sun, Z Zhang - Acta pharmacologica sinica, 2016 - nature.com
Aim: We previously reported a novel triptolide (TP)-glucosamine conjugate (TPG) that
specifically accumulated in kidneys and protected renal function from acute …

[HTML][HTML] Lasso peptide microcin J25 variant containing RGD motif as a PET probe for integrin av ß 3 in tumor imaging

K Mohri, KPH Nhat, M Zouda, S Warashina… - European Journal of …, 2023 - Elsevier
Abstract Microcin J25 (MccJ25), a lasso peptide, has a unique 3-D interlocked structure that
provides high stability under acidic conditions, at high temperatures, and in the presence of …

Feto-placental unit: from development to function

A Covarrubias, M Aguilera-Olguín… - Advances in Maternal …, 2023 - Springer
The placenta is an intriguing organ that allows us to survive intrauterine life. This essential
organ connects both mother and fetus and plays a crucial role in maternal and fetal well …