The Type VII Secretion System of Staphylococcus

L Bowman, T Palmer - Annual review of microbiology, 2021 - annualreviews.org
The type VII protein secretion system (T7SS) of Staphylococcus aureus is encoded at the
ess locus. T7 substrate recognition and protein transport are mediated by EssC, a …

The enigmatic Esx proteins: looking beyond mycobacteria

M Unnikrishnan, C Constantinidou, T Palmer… - Trends in …, 2017 - cell.com
Bacteria export proteins across membranes using a range of transport machineries. Type VII
secretion systems (T7SSs), originally described in mycobacteria, are now known to be …

Substrates control multimerization and activation of the multi-domain ATPase motor of type VII secretion

OS Rosenberg, D Dovala, X Li, L Connolly… - Cell, 2015 - cell.com
Mycobacterium tuberculosis and Staphylococcus aureus secrete virulence factors via type
VII protein secretion (T7S), a system that intriguingly requires all of its secretion substrates …

Type VII secretion: a highly versatile secretion system

LS Ates, ENG Houben, W Bitter - Virulence mechanisms of …, 2016 - Wiley Online Library
Bacterial secretion systems were initially studied in the Gram‐negative bacterium
Escherichia coli K‐12. When researchers started to explore protein secretion in different …

A membrane-depolarizing toxin substrate of the Staphylococcus aureus type VII secretion system mediates intraspecies competition

FR Ulhuq, MC Gomes, GM Duggan… - Proceedings of the …, 2020 - National Acad Sciences
The type VII protein secretion system (T7SS) is conserved across Staphylococcus aureus
strains and plays important roles in virulence and interbacterial competition. To date, only …

Extreme genetic diversity in the type VII secretion system of Listeria monocytogenes suggests a role in bacterial antagonism

K Bowran, T Palmer - Microbiology, 2021 - microbiologyresearch.org
The type VII protein secretion system (T7SS) has been characterized in members of the
phyla Actinobacteria and Firmicutes. In mycobacteria the T7SS is intimately linked with …

Interbacterial competition mediated by the type VIIb secretion system

ER Boardman, T Palmer, F Alcock - Microbiology, 2023 - microbiologyresearch.org
Successful occupancy of a given niche requires the colonising bacteria to interact
extensively with the biotic and abiotic environment, including other resident microbes …

Modeling tubercular ESX-1 secretion using Mycobacterium marinum

AE Chirakos, A Balaram, W Conrad… - … and Molecular Biology …, 2020 - Am Soc Microbiol
Pathogenic mycobacteria cause chronic and acute diseases ranging from human
tuberculosis (TB) to nontubercular infections. Mycobacterium tuberculosis causes both acute …

Type VII secretion systems in Gram-positive bacteria

D Bottai, MI Gröschel, R Brosch - Protein and sugar export and assembly …, 2017 - Springer
Bacterial secretion systems are sophisticated molecular machines that fulfil a wide range of
important functions, which reach from export/secretion of essential proteins or virulence …

WhiB6 regulation of ESX-1 gene expression is controlled by a negative feedback loop in Mycobacterium marinum

RE Bosserman, TT Nguyen… - Proceedings of the …, 2017 - National Acad Sciences
ESX (ESAT-6 system) export systems play diverse roles across mycobacterial species.
Interestingly, genetic disruption of ESX systems in different species does not result in an …