YAP/TAZ: drivers of tumor growth, metastasis, and resistance to therapy
BJ Thompson - Bioessays, 2020 - Wiley Online Library
The transcriptional co‐activators YAP (or YAP1) and TAZ (or WWTR1) are frequently
activated during the growth and progression of many solid tumors, including lung, colorectal …
activated during the growth and progression of many solid tumors, including lung, colorectal …
The Hippo pathway in intestinal regeneration and disease
The Hippo pathway is a signalling cascade conserved from Drosophila melanogaster to
mammals. The mammalian core kinase components comprise MST1 and MST2, SAV1 …
mammals. The mammalian core kinase components comprise MST1 and MST2, SAV1 …
Necroptosis microenvironment directs lineage commitment in liver cancer
M Seehawer, F Heinzmann, L D'artista, J Harbig… - Nature, 2018 - nature.com
Primary liver cancer represents a major health problem. It comprises hepatocellular
carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), which differ markedly with …
carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), which differ markedly with …
A time for YAP1: Tumorigenesis, immunosuppression and targeted therapy
M Shibata, K Ham, MO Hoque - International journal of cancer, 2018 - Wiley Online Library
YAP1 is one of the most important effectors of the Hippo pathway and has crosstalk with
other cancer promoting pathways. YAP1 contributes to cancer development in various ways …
other cancer promoting pathways. YAP1 contributes to cancer development in various ways …
[HTML][HTML] Cell of origin in biliary tract cancers and clinical implications
A Moeini, PK Haber, D Sia - JHEP Reports, 2021 - Elsevier
Biliary tract cancers (BTCs) are aggressive epithelial malignancies that can arise at any
point of the biliary tree. Albeit rare, their incidence and mortality rates have been rising …
point of the biliary tree. Albeit rare, their incidence and mortality rates have been rising …
Oncogenic driver genes and tumor microenvironment determine the type of liver cancer
G Wang, Q Wang, N Liang, H Xue, T Yang… - Cell death & …, 2020 - nature.com
Primary liver cancer (PLC) may be mainly classified as the following four types:
hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), hepatoblastoma …
hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC), hepatoblastoma …
Hippo signaling in the liver–a long and ever-expanding story
S Manmadhan, U Ehmer - Frontiers in cell and developmental biology, 2019 - frontiersin.org
The first description of Hippo signaling in mammals a little more than 10 years ago showed a
striking phenotype in the liver, linking the role of this signaling pathway to organ size control …
striking phenotype in the liver, linking the role of this signaling pathway to organ size control …
[HTML][HTML] Combined hepatocellular-cholangiocarcinoma: biology, diagnosis, and management
Background: Combined hepatocellular-cholangiocarcinoma (cHCC-iCCA) is a rare type of
primary liver cancer displaying characteristics of both hepatocytic and cholangiocytic …
primary liver cancer displaying characteristics of both hepatocytic and cholangiocytic …
[HTML][HTML] MYC determines lineage commitment in KRAS-driven primary liver cancer development
Background & Aims Primary liver cancer (PLC) comprises hepatocellular carcinoma (HCC)
and intrahepatic cholangiocarcinoma (iCCA), two frequent and lethal tumour types that differ …
and intrahepatic cholangiocarcinoma (iCCA), two frequent and lethal tumour types that differ …
[HTML][HTML] Emerging role of Hippo pathway in gastric and other gastrointestinal cancers
More evidence has underscored the importance of Hippo signaling pathway in
gastrointestinal tissue homeostasis, whereas its deregulation induces tumorigenesis. Yes …
gastrointestinal tissue homeostasis, whereas its deregulation induces tumorigenesis. Yes …