Genome projects are approaching completion and are saturating sequence databases. This
paper discusses the role of the two-hybrid system as a generator of hypotheses. Apart from …

The formation of extracellular vesicles (EVs) is induced by the sphingolipid ceramide. How
this pathway is regulated is not entirely understood. Here, we report that the ceramide …

Communication between the endoplasmic reticulum (ER) and mitochondria plays a pivotal
role in Ca2+ signaling, energy metabolism, and cell survival. Dysfunction in this cross-talk …

Centrin has been shown to be involved in centrosome biogenesis in a variety of eukaryotes.
In this study, we characterize hPOC5, a conserved centrin-binding protein that contains …

Disrupted In Schizophrenia 1 (DISC1) was identified as a potential susceptibility gene for
schizophrenia due to its disruption by a balanced t (1; 11)(q42; q14) translocation, which has …

The Shank family of proteins (also termed CortBP, ProSAP, or Synamon) is highly enriched
in the postsynaptic density (PSD) of excitatory synapses in brain. Shank contains multiple …

The type IIa Na+-dependent inorganic phosphate (Na/P i) cotransporter is localized in the
apical membrane of proximal tubular cells and is regulated by an endocytotic pathway …

Bacterial wilt caused by the soil-borne plant pathogen Ralstonia solanacearum is a
devastating disease worldwide. Upon plant colonization, R. solanacearum replicates …

Background Yeast two-hybrid (Y2H) screens have been among the most powerful methods
to detect and analyze protein-protein interactions. However, they suffer from a significant …

PDZK1: I. A major scaffolder in brush borders of proximal tubular cells. Background In
proximal tubular cells, PDZK1 (NaPi-Cap1) has been implicated in apical expression of the …