Prospects of optical biosensors for emerging label-free RNA analysis

LG Carrascosa, CS Huertas, LM Lechuga - Trac Trends in Analytical …, 2016 - Elsevier
RNA is critical in countless cellular processes, and researchers are constantly discovering
new types and attributing them different roles. Consequently, a growing interest in efficient …

[HTML][HTML] Functional nucleic acid-based biosensors for virus detection

Z Zhang, BR Adhikari, P Sen, L Soleymani, Y Li - Advanced Agrochem, 2023 - Elsevier
A growing number of viruses pose significant threats to human health, impact agricultural
production and compromise food safety. Minimizing the impact of viral infections demands …

Detection of Large Genomic RNA via DNAzyme‐Mediated RNA Cleavage and Rolling Circle Amplification: SARS‐CoV‐2 as a Model

J Gu, A Mathai, C Nurmi, D White… - … A European Journal, 2023 - Wiley Online Library
A new method for the detection of genomic RNA combines RNA cleavage by the 10‐23
DNAzyme and use of the cleavage fragments as primers to initiate rolling circle amplification …

[HTML][HTML] Unprecedently high targeting specificity toward lung ICAM-1 using 3DNA nanocarriers

N Roki, Z Tsinas, M Solomon, J Bowers… - Journal of Controlled …, 2019 - Elsevier
DNA nanostructures hold great potential for drug delivery. However, their specific targeting
is often compromised by recognition by scavenger receptors involved in clearance. In our …

DNA-based drug carriers: the paradox of a classical “cargo” material becoming a versatile “carrier” to overcome barriers in drug delivery

R Getts, S Muro - Current pharmaceutical design, 2016 - ingentaconnect.com
Drug delivery strategies help cope with drawbacks of classical pharmaceuticals, including
increasing their solubility, diminishing side effects and improving biodistribution. A multitude …

A DNA device that mediates selective endosomal escape and intracellular delivery of drugs and biologicals

S Muro - Advanced functional materials, 2014 - Wiley Online Library
Design of materials to aid intracellular delivery of agents can greatly improve medical
treatments. While DNA is a molecule difficult to introduce into cells, DNA can be engineered …

Tuning Design Parameters of ICAM-1-Targeted 3DNA Nanocarriers to Optimize Pulmonary Targeting Depending on Drug Type

N Roki, M Solomon, J Bowers, L Getts, RC Getts… - Pharmaceutics, 2022 - mdpi.com
3DNA holds promise as a carrier for drugs that can be intercalated into its core or linked to
surface arms. Coupling 3DNA to an antibody targeting intercellular adhesion molecule 1 …

Extended Release of Doxorubicin-Loaded 3DNA Nanocarriers from In-Situ Forming, Self-Assembled Hydrogels

LL Osorno, JDR Medina, DE Maldonado… - Journal of Ocular …, 2020 - liebertpub.com
Purpose: Cataracts are the leading cause of blindness worldwide, resulting in over 30
million surgeries each year. These cases are expected to double within the next 10 years …

A method to improve quantitative radiotracing‐based analysis of the in vivo biodistribution of drug carriers

N Roki, M Solomon, L Casta, J Bowers… - Bioengineering & …, 2021 - Wiley Online Library
Biodistribution studies are essential in drug carrier design and translation, and radiotracing
provides a sensitive quantitation for this purpose. Yet, for biodegradable formulations, small …

Large-Scale Generation of Synthetic DNA Libraries: Sequence-Specific Priming of Reverse Transcription.

YE Murgha - 2012 - deepblue.lib.umich.edu
Custom-designed DNA and RNA oligonucleotide collections are used as building blocks in
synthetic biology, complementary probes for targeted sequencing, and nucleic acid …